Aqueous ophthalmic solutions for the treatment of dryness and/or

Details Aqueous ophthalmic solutions for the treatment of dryness and/or Aqueous ophthalmic solutions for the treatment of dryness and/or

1986-09-04

1991-07-16

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514 39, 514725, A61K 3174, A61K 3170, A61K 3107

Patent

active

050323920

ABSTRACT:
An aqueous ophthalmic preparation is described for the treatment of dry and/or irritated eyes. The preparation is comprised of retinol and/or derivatives or precursors thereof, solubilized in water. Certain non-ionic surfactants and propylmethylcellulose are disclosed as solubilizing agents, with propylmethylcellulose also acting as a mucin-like constituent. The vitamin-containing preparation also contains (1) free radical scavenging compounds and (2) compounds capable, in solution, of chelating multivalent metal cations present in human and/or animal external eye tissue or tear film. The preferred free radical scavenger is mannitol. The preferred chelating agent is EDTA, present in minimal quantities for chelating certain catalytically active metallic ions present at or near the surface of the eye. Also described are tonicity adjusting compositions and an ophthalmic solution buffering system comprising citric acid and citrates.

REFERENCES:
patent: 3384545 (1968-05-01), Aiello et al.
patent: 4219545 (1980-08-01), Collins et al.
patent: 4409205 (1983-10-01), Shively
patent: 4421748 (1983-12-01), Trager et al.
Tseng et al.-Ophthalmology 92,717-727 (1985) "Topical Retinoid Treatment for Various Dryeye Disorders".
Tseng et al.-"Topical A Treatment for DryEye Disorders" 10-2-84, Science Writers Seminar in Ophthalmology.
Edelhauser et al.-Arch Ophthalmol. 93,648-655 & 657, "Intraocular Irrigating Solutions".
Chem. Abst. 96:223,307 p. (1982)-Urquhart.

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