Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-02-03
1997-02-04
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514 57, 514 59, 514724, 5147723, 514781, 514784, A61K 3155, A61K 4710, A61K 4712, A61K 4700
Patent
active
055998089
ABSTRACT:
Disclosed herein are aqueous indolocarbazole solutions. In one embodiment, the invention features a solution comprising: (1) an indolocarbazole; (ii) a selected organic solvent being present in a concentration of between about 1% and about 99% by weight inclusive, (iii) a dispersant being present in a concentration of between about 0.25% and about 10% by weight inclusive; (iv) water being present in a concentration of between 0% and about 99% by weight inclusive, and (v) a polyethylene glycol being present in a concentration of between 0% and about 60% by weight inclusive.
REFERENCES:
patent: 4877776 (1989-10-01), Murakata et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5043335 (1991-08-01), Kleinschroth et al.
patent: 5093330 (1992-03-01), Caravatti et al.
Berg et al. "K-252a Inhibits Nerve Growth Factor-induced trk Proto-oncogene Tyrosine Phosphorylation and Kinase Activity" J. Biol. Chem. 267:13-16 (1992).
Gribble et al., "Synthetic Approaches to Indolo[2,3-a]carbazole Alkaloids. Syntheses of Arcyriaflavin A and AT2433-B Aglycone," Tetrahedron 48:8869-8880, 1992.
Kase et al. "K-252 Compounds, Novel and Potent Inhibitors of Protein Kinase C & Cyclic Nucleotide-Dependent Protein Kinases" Biochem. and Biophys. Res. Comm. 142:436-440 (1987).
Moody et al. "Synthesis of the Staurosporine Aglycon" J. Org. Chem. 57:2105-2114 (1992).
Nakanishi et al. "K-252b, c and d, Potent Inhibitors of Protein Kinase C From Microbial Origin" J. Antibiot. 39:1066-1071 (1986).
Steglich et al. "Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria denudata" Angew. Chem. Ind. Ed. Engl. 19:459-460 (1980).
Yasuzawa et al. "The Structures of the Novel Protein Kinase C Inhibitors K-252a, b, c and d" J. Antibiot. 39:1072-1078 (1986).
Goldstein Joel D.
Herman Joseph L.
Cephalon Inc.
Weddington Kevin E.
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