Aqueous granulation solution and a method of tablet granulation

Details Aqueous granulation solution and a method of tablet granulation Aqueous granulation solution and a method of tablet granulation

1992-05-05

1994-09-20

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424484, 424717, 514819, 514960, 514970, A61K 946, A61K 916

Patent

active

053487451

ABSTRACT:
The invention discloses an aqueous granulating solution containing sodium, potassium or mixed sodium potassium salt of an edible organic acid selected from the group consisting of citric, malic, tartaric and fumaric acid and optionally containing sodium or potassium bicarbonate. The granulating solution is especially useful for granulating finely divided solids including acetaminophen, ketoprofen or calcium carbonate. The resulting granulate may be used to prepare a swallow tablet or mixed with an edible organic acid and the mixture tableted to provide an effervescent tablet without resorting to controlled reaction or special handling techniques.

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patent: 4716046 (1987-12-01), Lavie
patent: 4824664 (1989-04-01), Tarral et al.
patent: 4867942 (1989-09-01), Gergely et al.

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