Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1999-02-11
2000-05-30
Azpuru, Carlos A
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
A61F 202
Patent
active
060688505
ABSTRACT:
This invention relates to stable liquid aqueous formulations of peptide compounds at high concentrations. These stable formulations comprise at least about 10% peptide in water. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.
REFERENCES:
patent: 3914412 (1975-10-01), Gendrich et al.
patent: 4547370 (1985-10-01), Roeske
patent: 4661472 (1987-04-01), Rivier et al.
patent: 4689396 (1987-08-01), Roeske et al.
patent: 4851385 (1989-07-01), Roeske
patent: 5034229 (1991-07-01), Magruder et al.
patent: 5057318 (1991-10-01), Magruder et al.
patent: 5110596 (1992-05-01), Magruder et al.
patent: 5198533 (1993-03-01), Schally et al.
patent: 5413990 (1995-05-01), Haviv et al.
patent: 5480868 (1996-01-01), Kamei et al.
patent: 5482931 (1996-01-01), Harris et al.
patent: 5498598 (1996-03-01), Harris
Fu Lu, et al., "Percutaneous Absorption Enhancement of Leuprolide", Pharm. Res., 9(12):1575-1576 (1992).
Helm, et al., "Stability of Gonadorelin and Triptorelin in Aqueous Solution", Pharm. Res., 7(12):1253-1256 (1990).
Johnson, et al., "Degradation of the LH-RH Analog Nafarelin Acetate in Aqueous Solution", Intl. J. Pharm., 31:125-129 (1986).
Okada, et al., "Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers", Pharm. Res., 11(8):1143-1147 (1994).
Okada, et al., "New Degradation Product of Des-Gly.sup.10 -NH.sub.2 -LH-RH-Ethylamide (Fertirelin) in Aqueous Solution", J. Pharm. Sci., 80(2):167-170 (1991).
Oyler, et al., "Characterization of the Solution Degradation Products of Histrelin, a Gonadotropin Releasing Hormone (LH/RH) Agonist", J. Pharm. Sci., 80(3):271-275 (1991).
Powell, et al., "Peptide Liquid Crystals: Inverse Correlation of Kinetic Formation and Thermodynamic Stability in Aqueous Solution", Pharm. Res., 11(9):1352-1354 (1994).
Powell, et al., "Parenteral Peptide Formulations: Chemical and Physical Properties of Native Luteinizing Hormone-Releasing Hormone (LHRH) and Hydrophobic Analogues in Aqueous Solution", Pharm. Res., 8(10):1258-1263 (1991).
Powers, et al., "Solution Behavior of Leuprolide Acetate, an LHRH Agonist, as Determined by Circular Dichroism Spectroscopy", Intl. J. Pharm.,108:49-55 (1994).
Shi, et al., "Long-Term Stability of Aqueous Solutions of Luteinizing Hormone-Releasing Hormone Assessed by an In-Vitro Bioassay and Liquid Chromatography", J. Pharm. Sci., 73(6):819-821 (1984).
Toguchi, "Pharmaceutical Manipulation of Leuprorelin Acetate to Improve Clinical Performance", J. Intl. Med. Res., 18:35-41 (1990).
Factrel (gonadorelin HCI for subcutaneous or IV injection), Physician's Desk Reference, 50th Edition, pp. 2877-2878 (1996).
Lupron (leuprolide acetate for subcutaneous injection), Physician's Desk Reference, 50th Edition, pp. 2555-2556 (1996).
Lupron Depot (leuprolide acetate for depot suspension), Physician's Desk Reference, 50th Edition, pp. 2556-2562 (1996).
Lutrepulse (gonadorelin acetate for IV injection), Physician's Desk Reference, 50th Edition, pp. 980-982 (1996).
Zoladex (goserelin acetate implant), Physician's Desk Reference, 50th Edition, pp. 2858-2861 (1996).
Eckenhoff, deceased James B.
Leonard, Jr. John J.
Prestrelski Steven J.
Stevenson Cynthia L.
Tao Sally A.
ALZA Corporation
Azpuru Carlos A
Clarke Pauline A.
Dillahunty Mary Ann
Stone Steven F.
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