Aqueous folinate solution stable at refrigerator temperature, as

Details Aqueous folinate solution stable at refrigerator temperature, as Aqueous folinate solution stable at refrigerator temperature, as

1989-11-21

1993-01-05

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514970, A61K 31495

Patent

active

051770768

ABSTRACT:
An aqueous folinate solution stable at refrigerator temperature is provided which contains folinate ions, complexed calcium ions, and if desired free calcium ions in a total amount of more than 12 mg/ml, as well as anions of a complexing agent for calcium. This solution is prepared by incorporating the complexing agent therein.

REFERENCES:
patent: 2695860 (1954-11-01), Weidenheimer et al.
patent: 4344940 (1982-08-01), Chow et al.
patent: 4436738 (1984-03-01), Bequette et al.
Bundesverband der Pharmazeutischen Industrie "Roto Liste", 1989, Editio Cantor, Aulendorf/Wurtt., De No. 12-022 Leucovorin.
Journal of Phamaceutical Sciences, vol. 69, No. 2, Feb. 1980, blz. 234, American Pharmaceutical Assocation; K. R. Scott et al.: "Drug interactions I: folic acid and calcium gluconate".

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