Aqueous enteric coating composition and low gastric permeability

Details Aqueous enteric coating composition and low gastric permeability Aqueous enteric coating composition and low gastric permeability

1998-09-29

2000-10-31

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424481, 424482, A61K 942

Patent

active

061398756

ABSTRACT:
Disclosed herein is an aqueous enteric coating composition comprised of a solution of a water-soluble salt of an enteric coating polymer, with a hydrophobic compound containing 12 to 20 carbon atoms and a water-insoluble solid flake material dispersed in the aqueous solution. The enteric coating formed from the present composition has good mechanical strength and shows superior resistance to attack by atmospheric moisture and simulated gastric fluid, while being readily broken down under the alkaline conditions which exist in the intestine.

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