Aqueous dispersions of lipid spheres and compositions containing

Details Aqueous dispersions of lipid spheres and compositions containing Aqueous dispersions of lipid spheres and compositions containing

1979-12-12

1988-09-20

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 59, 424 62, 424 63, 424 89, 424 943, 424498, 4284022, 42840221, 514474, 514887, 514944, A61K 962, A61K 3722, B01J 1302

Patent

active

047724714

ABSTRACT:
A dispersion in a continuous phase or spherules comprises arranged molecular layers of a non-ionic lipid compound encapsulating an aqueous phase wherein the non-ionic lipid compound has a lipophile group/hydrophile group ratio such that the non-ionic lipid compound swells in the aqueous phase to be encapsulated therein so as to form a lamellar phase. The hydrophile group of the non-ionic compound is selected from the group consisting of polyoxyethylene groups, polyglycerol groups and esters of polyols. The spherules have a diameter between 1,000 .ANG. and 50,000 .ANG..

REFERENCES:
patent: 3041289 (1962-06-01), Katchen et al.
patent: 3630920 (1971-12-01), Freifeld et al.
patent: 3686701 (1972-08-01), Charle et al.
patent: 3932657 (1976-01-01), Rahman
patent: 4217344 (1980-08-01), Vanlerberghe et al.
Ruckenstein et al.: "Thermodynamics of Amphiphilar Aggregation Into Micelles and Vesicles", Micellization, Solubilization, and Microemulsions, vol. 1, Edited by Mittal, Plenum Press, New York.
Israelachvili et al.: "Theory of Self-Assembly of Lipid Bilayers and Vesicles", Biochimica et Biophysica Acta, 470 (1977), 185-201.
Israelachvili et al.: "Theory of Self-Assembly of Hydrocarbon Amphiphiles Into Micelles and Bilayers", pp. 1526-1568, Rec'd. Nov. 7, 1975.
Hargreaves Thesis, "Monoalkyl Liposomes, Prebiotic Glycerolipids, and Possible Origins of Biological Membranes", 1978.
Sessa et al.: "Incorporation of Lysozyme Into Liposomes", J. of Biol. Chem., vol, 245, No. 13, Jul. 10, 1970, pp. 3295-3301.
Kinsky et al.: "Effect of Cholesterol Incorporation on the Sensitivity of Liposomes to the Polyene Antibiotic, Filipin", Biochim. Biophys. Acta, 152 (1968), 174-185.
Tanford: "The Hydrophobic Effect: Formation of Micelles and Biological Membranes", Wiley-Interscience Publ., John Wiley & Sons, New York, pp. 78 & 79.

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