Aqueous creatine solution and process of producing a stable, bio

Details Aqueous creatine solution and process of producing a stable, bio Aqueous creatine solution and process of producing a stable, bio

1998-02-26

1999-10-26

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562560, A61K 31195

Patent

active

059730056

ABSTRACT:
A stable aqueous solution of creatine acid sulfate provides a source of creatine to an animal when taken orally. The aqueous solution of creatine acid sulfate (after neutralization and buffering) has a pH of about 7.2 to about 7.8 and is stable for at least six months at room temperature. The creatine acid sulfate is produced by adding creatine monohydrate to a sulfuric acid solution in a stoichiometric amount to result in creatine acid sulfate having a pH initially of 2.0-3.0. The resulting creatine acid sulfate is diluted with water and neutralized to raise the pH and avoid the formation of creatinine. The resulting creatine acid sulfate solution preferably contains a buffering and neutralizing agent such as tribasic potassium phosphate which forms mono- and dibasic potassium phosphates by interaction with the hydrogen ions liberated from the acid sulfate. The aqueous solution can be combined with a sweetener, electrolyte and carbohydrate source to produce a stable drink for providing a source of creatine to an animal in need thereof. An effective amount of glycerol is preferably added to enhance absorption of the creatine through the intestinal wall into the bloodstream and eventually to the needy skeletal muscles.

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Martindale, The Extra Pharmacopoeia, The Pharmaceutical Press 1982, Anhydrous Sodium Phosphate/Proprietary Preparations of Some Other Electrolyte Solutions, p. 643.
Creatine Phosphate Research Underway, http://ussa-sport.ussa.edu/pubs/creatin.num, Feb. 5, 1997.
Edgar et al., The Equilibrium Between Creatine and Creatinine, in Aqueous Solution. The Effect of Hydrogen Ion, J. Am. Chem. Soc., vol. 47, pp. 1179-1188, Apr. 4, 1925.
Dhar et al, Chem. Abstracts, vol. 56, #9702h, 1961.
Dhar et al, Chem. Abstracts, vol. 56, #9703a, 1961.

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