Aqueous compositions containing metronidazole

Details Aqueous compositions containing metronidazole Aqueous compositions containing metronidazole

2005-04-19

2005-04-19

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S398000

Reexamination Certificate

active

06881726

ABSTRACT:
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is a compound other than a cyclodextrin. Methods of manufacture and therapeutic use of the solution are disclosed.

REFERENCES:
patent: 6468989 (2002-10-01), Chang et al.
patent: WO 9909988 (1999-03-01), None
Redenti, E. et al “Drug/cyclodextrin/hydroxy acide multicomponent systems” J. Pharm. Sci. (2000) vol. 89, No 1, pp. 1-8.

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