Aqueous antimicrobial ophthalmic solutions

Details Aqueous antimicrobial ophthalmic solutions Aqueous antimicrobial ophthalmic solutions

1983-09-29

1985-06-25

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Lymphokine

424 78, 514642, A61K 3174, A61K 3179, A61K 3114

Patent

active

045253463

ABSTRACT:
This invention relates to ophthalmic compositions which comprise quaternary ammonium salt having the formula ##STR1## wherein X=a pharmaceutically acceptable anion, such compositions providing aqueous disinfecting solutions for contact lenses as well as a preserved ocular compositions including contact lens treating solutions comfort drop solutions, preserved saline solutions, ointments and other ocular medicaments.

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Onamer-M-A Product Bulletin LRSBD 12177, Onyx Chemical Company, New York, N.Y.
Refojo, 1972, "Reversible Binding of Chlorhexidine Gluconate to Hydrojel Contact Lenses"; Contact and Intraocular Lens Med. J., 2, pp. 47-56.
Petrocci et al., 1978 "Quaternary Ammonium Antimicrobial Compounds:Old and New", Developments in Industrial Microbiology 20:11-14.
Richardson et al., 1978, "The Interaction of Preservatives with Polyhydroxyethylmethacrylate(PolyHEMA)", J. of Pharm. Pharmac., 30:469-475.
Kaspar, 1976, "Binding Characteristics and Microbiological Effectiveness of Preservatives", Australian Journal of Optometry, pp. 3-8.
Letter from Petrocci to Randeri dated Oct. 19, 1981.

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