Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-04-24
2011-11-15
Lu, Frank W (Department: 1634)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023200, C536S024300, C536S024330, C536S025300, C435S006120, C435S091100
Reexamination Certificate
active
08058415
ABSTRACT:
The present invention provides aptamer- and nucleic acid enzyme-based systems for simultaneously determining the presence and optionally the concentration of multiple analytes in a sample. Methods of utilizing the system and kits that include the sensor components are also provided. The system includes a first reactive polynucleotide that reacts to a first analyte; a second reactive polynucleotide that reacts to a second analyte; a third polynucleotide; a fourth polynucleotide; a first particle, coupled to the third polynucleotide; a second particle, coupled to the fourth polynucleotide; and at least one quencher, for quenching emissions of the first and second quantum dots, coupled to the first and second reactive polynucleotides. The first particle includes a quantum dot having a first emission wavelength. The second particle includes a second quantum dot having a second emission wavelength different from the first emission wavelength. The third polynucleotide and the fourth polynucleotide are different.
REFERENCES:
patent: 4362603 (1982-12-01), Presson et al.
patent: 4703017 (1987-10-01), Campbell et al.
patent: 4746631 (1988-05-01), Clagett
patent: 4855240 (1989-08-01), Rosenstein et al.
patent: 4857319 (1989-08-01), Crowe et al.
patent: 5008109 (1991-04-01), Tin
patent: 5459040 (1995-10-01), Hammock et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5580967 (1996-12-01), Joyce
patent: 5593835 (1997-01-01), Rando et al.
patent: 5631148 (1997-05-01), Urdea
patent: 5663064 (1997-09-01), Burke et al.
patent: 5807718 (1998-09-01), Joyce et al.
patent: 5807967 (1998-09-01), Snow et al.
patent: 5910408 (1999-06-01), Szostak et al.
patent: 5989813 (1999-11-01), Gerdes
patent: 6040138 (2000-03-01), Lockhart et al.
patent: 6110462 (2000-08-01), Barbas et al.
patent: 6159347 (2000-12-01), Sumner, Jr. et al.
patent: 6287765 (2001-09-01), Cubicciotti
patent: 6316194 (2001-11-01), Karn et al.
patent: 6326508 (2001-12-01), Godbole et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6387617 (2002-05-01), Asher et al.
patent: 6426335 (2002-07-01), Janjic et al.
patent: 6451535 (2002-09-01), Jenne et al.
patent: 6485982 (2002-11-01), Charlton
patent: 6541617 (2003-04-01), Bamdad et al.
patent: 6630306 (2003-10-01), Breaker
patent: 6706474 (2004-03-01), Lu et al.
patent: 6818455 (2004-11-01), May et al.
patent: 6843890 (2005-01-01), Godbole
patent: 6849414 (2005-02-01), Guan et al.
patent: 6890719 (2005-05-01), Lu et al.
patent: 7109165 (2006-09-01), Matulic-Adamic et al.
patent: 7192708 (2007-03-01), Lu et al.
patent: 7332283 (2008-02-01), Lu et al.
patent: 7612185 (2009-11-01), Lu et al.
patent: 7799554 (2010-09-01), Mazumdar et al.
patent: 7892734 (2011-02-01), Lu et al.
patent: 7902353 (2011-03-01), Lu et al.
patent: 7906320 (2011-03-01), Lu et al.
patent: 2003/0149257 (2003-08-01), Sorge et al.
patent: 2003/0215810 (2003-11-01), Lu et al.
patent: 2003/0235611 (2003-12-01), Ehringer et al.
patent: 2004/0018515 (2004-01-01), Diener et al.
patent: 2004/0126882 (2004-07-01), Ellington et al.
patent: 2004/0158051 (2004-08-01), Ozkan et al.
patent: 2004/0175693 (2004-09-01), Lu et al.
patent: 2005/0037075 (2005-02-01), Farokhzad et al.
patent: 2005/0136500 (2005-06-01), Yang et al.
patent: 2005/0282186 (2005-12-01), Lu et al.
patent: 2006/0019406 (2006-01-01), Wei et al.
patent: 2006/0040408 (2006-02-01), Jones et al.
patent: 2006/0045910 (2006-03-01), Ehringer
patent: 2006/0094026 (2006-05-01), Lu et al.
patent: 2006/0166222 (2006-07-01), Lu et al.
patent: 2007/0037171 (2007-02-01), Lu et al.
patent: 2007/0269821 (2007-11-01), Mazumdar et al.
patent: 2008/0176228 (2008-07-01), Lu et al.
patent: 2009/0011402 (2009-01-01), Lu et al.
patent: 2009/0029874 (2009-01-01), Lu et al.
patent: 2009/0098550 (2009-04-01), Lu et al.
patent: 2009/0197261 (2009-08-01), Lu et al.
patent: 2010/0105039 (2010-04-01), Lu et al.
patent: 2010/0151579 (2010-06-01), Wang et al.
patent: 2010/0166842 (2010-07-01), Lu et al.
patent: 2011/0123982 (2011-05-01), Lu et al.
patent: 121970 (1984-10-01), None
patent: 1219708 (2002-07-01), None
patent: 1 312 674 (2003-05-01), None
patent: 2339280 (2000-01-01), None
patent: WO 91/14696 (1991-10-01), None
patent: WO 96/17086 (1996-06-01), None
patent: WO 97/09342 (1997-03-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/27104 (1998-06-01), None
patent: WO 98/39484 (1998-09-01), None
patent: WO 98/49346 (1998-11-01), None
patent: WO 99/13338 (1999-03-01), None
patent: WO 99/27351 (1999-06-01), None
patent: WO 99/47704 (1999-09-01), None
patent: WO 00/26226 (2000-05-01), None
patent: WO 00/58505 (2000-10-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/23548 (2001-04-01), None
patent: WO 01/24696 (2001-04-01), None
patent: WO 01/27612 (2001-04-01), None
patent: WO 01/27612 (2001-04-01), None
patent: WO 01/51665 (2001-07-01), None
patent: WO 01/73123 (2001-10-01), None
patent: WO 02/00006 (2002-01-01), None
patent: WO 02/22882 (2002-03-01), None
patent: WO 02/098364 (2002-12-01), None
patent: WO 03/062422 (2003-07-01), None
patent: WO 03/068963 (2003-08-01), None
patent: WO 03/094838 (2003-11-01), None
patent: WO 03/095648 (2003-11-01), None
patent: WO 2004/046687 (2004-06-01), None
patent: WO 2004/081235 (2004-09-01), None
patent: WO 2005/082922 (2005-09-01), None
patent: WO 2005/095967 (2005-10-01), None
patent: WO 2005/100602 (2005-10-01), None
patent: WO 2006/020768 (2006-02-01), None
patent: WO 2006/020786 (2006-02-01), None
patent: WO 2006/048164 (2006-05-01), None
patent: WO 2006/052419 (2006-05-01), None
patent: WO 2006/078660 (2006-07-01), None
patent: WO 2007/106118 (2007-09-01), None
patent: WO 2007/109500 (2007-09-01), None
patent: WO 2008/089248 (2008-07-01), None
patent: WO 2009/012309 (2009-01-01), None
patent: WO 2009/045632 (2009-04-01), None
“What wavelength goes with a color” from eosweb. larc. Nasa.gov. Printed on Jan. 7, 2011.
Cadmium sulfide from Wikipedia, the free encyclopedia. Printed on Jan. 7, 2011.
Yeh et al., Quantum dot-mediated biosensing assays for specific nucleic acid detection. Nanomedicine, 1, 115-121, 2005.
Abstract of Joyce, G., “Design and catalytic activity of enzyumic DNA molecules”., (1998).
Aggarwal, S.K., et al., “Determination of lead in urine and whole blood by stable isotope dilution gas chromatography-mass spectrometry”., Clinical Chemistry, vol. 40, No. 8, pp. 1494-1502, (1994).
Alivisatos, A.P., et al., “Organization of “nanocrystal molecules” using DNA”., Nature, vol. 382, pp. 609-611, (1996).
Allara, D. et al., “Spontaneously organized molecular assemblies. 1.Formation, dynamics and physical properties of n-alkanoic acids adsorbed from solution on an oxidized aluminum surface”., Langmuir, vol. 1, No. 1, pp. 45-52, (1985).
Andreola, M-L., et al., “DNA aptamers selected against the HIV-1 RNase H display in vitro antiviral activity”., Biochemistry, vol. 40, No. 34, pp. 10087-10094, (2001).
Bain, C. D., et al., “Modeling organic surfaces with self-assembled monolayers”., Angew. Chem. Int. Ed. Engl., vol. 28, No. 4, pp. 506-512, (1989).
Bannon, D.I., et al., “Graphite furnace atomic absorption spectroscopic measurement of blood lead in matrix-matched standards”., Clinical Chemistry, vol. 40, No. 9, pp. 1730-1734, (1994).
Been, M.D., et al., “Self-cleaving ribozymes of hepatitis delta virus RNA”., Eur. J. Biochem., vol. 247, pp. 741-753 (1997).
Berens, C., et al., “A tetracycline-binding RNA aptamer”., Bioorganic & Medicinal Chemistry, vol. 9, pp. 2549-2556, (2001).
Biroccio, A., et al., “Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase”., Journal of Virology, vol. 76, No. 8, pp. 3688-3696, (2002).
Blake, D.A., et al., “Antibody-based sensors for heavy metal ions”., Biosensors & Bioelectronics, vol. 16, pp. 799-809, (2001).
Blank, M., et al., “Systematic evolution of a DNS aptamer binding to rat brain tumor microvessels. Sel
Liu Juewen
Lu Yi
Klarquist & Sparkman, LLP
Lu Frank W
The Board of Trustees of the University of Illinois
LandOfFree
Aptamer- and nucleic acid enzyme-based systems for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aptamer- and nucleic acid enzyme-based systems for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aptamer- and nucleic acid enzyme-based systems for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4282724