Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-05-18
1997-04-15
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530303, 530350, A61K 3800, A61K 3828, C07K 500, C07K 100
Patent
active
056210744
ABSTRACT:
The present invention relates to methods for producing aprotinin and analogs thereof in yeast, synthetic genes encoding such products, expression vectors and transformed yeast cells. The invention further relates to aprotinin analogs, particularly analogs with increased specific inhibitory activity and/or reduced nephrotoxicity compared to native aprotinin, as well as compositions comprising such analogs.
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Bj.o slashed.rn Soren E.
Bregengaard Claus
Christensen Niels D.
Diness Viggo
N.o slashed.rskov-Lauritsen Leif
Agris, Esq. Cheryl H.
Hobbs Lisa J.
Novo Nordisk A S
Wax Robert A.
Zelson Esq. Steve T.
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