Approaches to identify less harmful tobacco and tobacco...

Details Approaches to identify less harmful tobacco and tobacco... Approaches to identify less harmful tobacco and tobacco...

2005-05-11

2010-02-16

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007210, C435S007230

Reexamination Certificate

active

07662565

ABSTRACT:
Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained from tobacco or tobacco products induces double stranded breaks in cellular DNA, which were efficiently detected using assays that measure the presence, absence, or amount of phosphorylation of the histone, H2AX.

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