Approach to anti-microbial host defense with molecular...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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C514S552000, C514S549000

Reexamination Certificate

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07030159

ABSTRACT:
Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. Various BPI inducing agents include icosapentanoic acid (EPA) analogs and docosahexaenoic acid (DHA) analogs.

REFERENCES:
patent: 4201211 (1980-05-01), Chandrasekaran et al.
patent: 4666701 (1987-05-01), Horrobin et al.
patent: 4810424 (1989-03-01), Gerwick et al.
patent: 5409955 (1995-04-01), Bockow et al.
patent: 5411988 (1995-05-01), Bockow et al.
patent: 5604258 (1997-02-01), Ferrante et al.
patent: 5709855 (1998-01-01), Bockow et al.
patent: 5814599 (1998-09-01), Mitragotri et al.
patent: 5846974 (1998-12-01), Kallman et al.
patent: 6117911 (2000-09-01), Grainger et al.
patent: 6201022 (2001-03-01), Mease et al.
patent: XP-002184773 (1990-07-01), None
patent: 5186342 (1993-07-01), None
patent: WO 91/16914 (1991-11-01), None
patent: WO 98/46588 (1998-10-01), None
Karanian, J.W. et al., “Physiological functions of hydroxy-docosahexaenoic acid”, Abstract, XP-002200246, 1993.
Hill, E.M. et al., “Identification and egg hatching activity of monohydroxy fatty acid eicosanoids in the barnacleBalanus balanoides”, Abstract, XP-002200247, 1992.
Ganz, T. et al., “Antimicrobial peptides of phagocytes and epithelia”,Seminars in Hematology,vol. 34, No. 4, 1997, pp. 343-354.
Elsbach, P. et al., “Role of the bactericidal/permeability-increasing protein in host defence”,Current Opinion in Immunology,vol. 10, No. 1, 1998, pp. 45-49.
Levy, O., “A neutrophil-derived anti-infective molecule; bactericidal/permeability-increasing protein”,Antimicrobial Agents and Chemotherapy,vol. 44, No. 11, 2000, pp. 2925-2931.
Levy, O., “Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents”,Blood,vol. 96, No. 8, 2000, pp. 2664-2672.
Beamer, L.J. et al., “Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution”,Science,vol. 276, 1997, pp. 1861-1864.
Lockhart, D.J. et al., “Expression monitoring by hybridization to high-density oligonucleotide arrays”,Nature Biotechnology,vol. 14, No. 13, 1996, pp. 1675-1680.
Serhan, C.N. et al., “Novel functional sets of lipid-derived mediators with anti-inflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal anti-inflammatory durgs and transcellular processing”,J. Exp. Med.,vol. 192, No. 8, 2000, pp. 1197-1204.
Serhan, C.N. et al., “Resolvins: a family of bioactive products of mega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals”,J. Exp. Med.,vol. 196, No. 8, 2002, pp. 1025-1037.
Canny, G. et al., “Lipid mediator-induced expression of bactericidal/permeability-increasing protein (BPI) in human mucosal epithelia”,Proc. Natl. Acad. Sci. USA,vol. 99, No. 6. 2002, pp. 3902-3907.
Dharmsathaphorn, K. et al., “Established intestional cell lines as model systems for electrolyte transport studies”,Methods in Enzymology,vol. 192, 1990, pp. 354-389.
Eckmann, L. et al., “Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry”,Infection and Immunity,vol. 61, No. 11, 1193, pp. 4569-4574.
Higuchi, R. et al., “Kinetic PCR analysis: real-time monitoring of DNA amplification reactions”,Biotechnology,vol. 11, 1993, pp. 1026-1030.
Taylor, C.T. et al., “Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-a”,J. Biolog. Chem.,vol. 274. No. 27, 1999, pp. 19447-19454.
Pfaffl, M.W., “A new mathematical model for relative quantification in real-time RT-PCR”,Nucleic Acids Research,vol. 29, No. 9, 2001, pp. 2002-2007.
McCormick, B.A. et al., “Salmonella typhimuriumattachment to human intestinal epithelial monolayers: transcellular signaling to subepithelial neurophils”,J. Cell Biology,vol. 123, No. 4, 1993, pp. 895-907.
Colgan, S.P. et al., “Defective invitro motility of polymorphonuclear leukocytes of homozygotte and heterozygote Chediak-Higashi cats”,Vet. Immunol. Immunopathology,1992, pp. 205-227.
Weersink, A., et al., “Human granulocytes express a 550-kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein”,J. Immunology,vol. 150, No. 1, 1993, pp. 253-263.
Weiss, J. et al., “Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes”,J. Biol. Chem.,vol. 253, No. 8, 1978, pp. 2664-2672.
Kato, T. et al., “Production of Hydroxy Unsaturated Fatty Acids Using Crude Lipoxygenase Obtained from Infected Rice Plants”,Bull. Chem. Soc, Jpn.,vol. 69, 1996, pp. 1663-1666.
De Montarby, L. et al., “Syntheses stereoselectives de metabolites hydroxyls d'acides gras polyinsatures”,Bulletin De La Societe Chimique de France,No. 3, 1989, pp. 419-432.
Yamane, M. et al., “ Docosahexanenoic/arachidonic acid ω-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2”,Cancer Letters,vol. 122, 1998, pp. 51-59.
Iigo, M. et al., “Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung”,Br. J. Cancer,1997, pp. 650-655.
Billman, G.E. et al., “Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs”,Circulation 991999, pp. 2452-2457.
Simopoulos, A.P., “Workshop on the essentiality of an recommended dietary intakes for omega-6 and omega-3 fatty acids”,J. Am. Coll. Nutr.1999, pp. 487-489.
Marchioloi, R., “Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial”,Lancet1999, pp. 447-455.
Weissmann, G., “Aspirin”,Sci. Am.1991, pp. 84-90.
Marcus, A.J., “Platelents: their role in hemostasis, thrombosis, and inflammation”,Inflammation: Basic Principles and Clinical Correlates1999, pp. 77-95.
Claria, J. et al., “Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions”,Proc. Natl. Acad. Sci.USA 1995, pp. 9475-9479.
Serhan, C.N. et al, “Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils”,Biochemistry1995, pp. 14609-14615.
Chiang, N. et al., “Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion”,J. Clin. Invest.1999, pp. 309-316.
Herschman, H.R., “Recent progress in the cellular and molecular biology of prostaglandin synthesis”,Trends Cardiovasc. Med.1998, pp. 145-150.
Needleman, P. et al., “The discovery and function of COX-2”,J. Rheumatol1997, pp. 6-8.
Chiang, N. et al., “Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: Development of a specific 15-epi-LXA4 ELISA”,J. Pharmacol Exp. Ther.1998, pp. 779-790.
Xiao, G. et al., “Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2”,Biochemistry1997, pp. 1836-1845.
Node, K. et al., “Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids”,Science1999, pp. 1276-1279.
Sethi, S. et al., “Inhibition of phagocyte-endothelium interactions by oxidized fatty acids: A natural anti-inflammatory mechanism?”,J. Lab. Clin. Med.1996, pp. 27-38.
Levy, G.N., “Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer”,FASEB J.1997, pp. 234-247.
Gronert, K. et al., “Transcellular regulation of eicosanoid biosynthesis”,Eicosanoid Protocols1999, pp. 119-144.
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