Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1992-08-17
1994-06-07
Cohen, Lee S.
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
607145, 607150, A61N 130
Patent
active
053185145
ABSTRACT:
An apparatus for implanting macromolecules such as genes, DNA or pharmaceuticals into a preselected surface tissue region of of a patient. An applicator having a plurality of electrodes is provided for contacting a surface tissue region of a patient. A mechanism associated with the applicator delivers a predetermined quantity of a fluid medium carrying the preselected macromolecules. A signal generator is provided for generating a predetermined electric signal. The electrodes of the applicator are connected to the signal generator for applying an electric field in the surface tissue region. The field has a predetermined strength and duration in order to make the walls of a plurality of cells in the surface tissue region transiently permeable to permit the macromolecules to enter said preselected cells without damaging said cells. This enhances the uptake of macromolecules and thus enhances the therapeutic effect achieved.
REFERENCES:
patent: 4033356 (1977-07-01), Hara
patent: 4090517 (1978-05-01), Takenaka
patent: 4180079 (1979-12-01), Wing
patent: 4689039 (1987-08-01), Masaki
patent: 4837049 (1989-06-01), Byers et al.
patent: 4942883 (1990-07-01), Newman
patent: 4953565 (1990-09-01), Tachibana et al.
patent: 4997418 (1991-03-01), DeMartini
patent: 5002527 (1991-03-01), Reller et al.
patent: 5012816 (1991-05-01), Lederer
patent: 5019034 (1991-05-01), Weaver et al.
patent: 5037381 (1991-08-01), Bock et al.
patent: 5084008 (1992-01-01), Phipps
patent: 5156591 (1992-10-01), Gross et al.
patent: 5160316 (1992-11-01), Henley
patent: 5162042 (1992-11-01), Gyory et al.
patent: 5162043 (1992-11-01), Lew et al.
BTX Inc.
Cohen Lee S.
Gilbert Samuel
LandOfFree
Applicator for the electroporation of drugs and genes into surfa does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Applicator for the electroporation of drugs and genes into surfa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Applicator for the electroporation of drugs and genes into surfa will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-789790