Applications of peptides derived from the cytoplasmic domain...

Details Applications of peptides derived from the cytoplasmic domain... Applications of peptides derived from the cytoplasmic domain...

2006-10-03

2006-10-03

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120, C530S324000

Reexamination Certificate

active

07115380

ABSTRACT:
The invention concerns novel uses of peptides derived from the cytoplasmic domain of the amyloid protein precursor (APP); said peptides are in particular sequences including the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP) (one-letter code), selected in the group consisting of the sequences Y1KQYTSIHHGY0(SEQ ID NO:2). Y1KKQYTSIHHGY0(SEQ ID NO:3) and Y1KKKQYTSIHHGY0(SEQ ID NO:4), wherein Y0is nil or represents V, VV, VVE, VVEV or VVVED and Y1represents an internalisation and addressing peptide, derived from the 3rd helix of homeodomains and structually related peptides. The invention also concerns the use of a peptide comprising the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP), for selecting and screening products capable of inhibiting apoptosis.

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patent: 5703209 (1997-12-01), Vitek et al.
patent: 6080724 (2000-06-01), Chassaing et al.
patent: WO 93/07296 (1993-04-01), None
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patent: WO 98/28334 (1998-07-01), None
patent: WO 98/38861 (1998-09-01), None

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