Application of resins consisting of functional polymers as the s

Details Application of resins consisting of functional polymers as the s Application of resins consisting of functional polymers as the s

1988-04-15

1992-06-16

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

530413, 530412, C07K 318

Patent

active

051225972

ABSTRACT:
The present invention relates to the application, as the stationary phase in affinity chromatography for the purification of the FGF type growth factors, of the polymers or copolymers onto which --SO.sub.3 H and --SO.sub.3 M groups are randomly bound, groups in which M denotes a physiologically acceptable metal, as well as, preferably, --SO.sub.2 R groups, in which R denotes a radical obtained by removal of a hydrogen atom from the amino group of an amino acid or an amino acid derivative.
The invention relates also to the obtaining of a purified bFGF or aFGF growth factor, or a mixture of these growth factors, consisting in carrying out an affinity chromatography on a resin such as defined hereinabove, by carrying out an elution with a neutral pH buffer having an ionic strength equivalent to that of a 0.15 M to 2.5 M NaCl solution.

REFERENCES:
patent: 4755379 (1988-07-01), Jozefonvicz et al.
patent: 4785079 (1988-11-01), Gospodarowicz

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