Application of protein-protein interaction as an assay for the d

Details Application of protein-protein interaction as an assay for the d Application of protein-protein interaction as an assay for the d

1976-09-29

1979-07-10

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260112B, 424 12, 424177, A61K 4300, G01N 3316

Patent

active

041608178

ABSTRACT:
A specific type of protein, which has been designated B-protein (Bucovaz-protein), is present in most serum of individuals with cancer. The B-protein interacts with a low molecular weight protein component, which is released by the coenzyme A-synthesizing protein complex (CoA-SPC) of Bakers' yeast during the course of CoA synthesis. This low molecular weight protein, for purposes of identification, is referred to as binding protein. The binding protein has a molecular weight of 10,000 to 15,000. Interaction of radioactively labeled binding protein of CoA-SPC with the B-protein of serum provides a marker for the detection of cancer. Of 3005 serums assayed, which included 908 patients diagnosed as having cancer, the B-protein assay agreed with the clinical diagnosis in more than 89% of the cases.

REFERENCES:
bucovaz et al., Proc. Am. Assoc. Cancer Research, 16(1975) Abstract for oral presentation, p. 80.

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