Application of aprataxin gene to diagnosis and treatment for...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

07824860

ABSTRACT:
The present invention provides polynucleotides and proteins, which are involved in early-onset spinocerebellar ataxia with ocular motor apraxia and hypoalbuminemia (EAOH); and methods of using the polynucleotides and/or proteins to treat and/or diagnose EAOH.

REFERENCES:
patent: 2003/0092019 (2003-05-01), Meyer et al.
patent: WO 01/55376 (2001-08-01), None
Hirschhorn et al. (Genetics in Medicine. vol. 4, No. 2, pp. 45-61, Mar. 2002).
Ioannidis (Nature Genetics, vol. 29, pp. 306-309, Nov. 2001).
Lucentini (The Scientist; 2004, vol. 24, p. 20).
Date et al. (Nature Genetics, vol. 29, pp. 184-188, Oct. 2001).
Moreira et al. (Nature Genetics, vol. 2, pp. 189-193, Oct. 2001).
NCBI database Accession Nos. BAA90985 (protein) & AK000164 (nucleic acid), GI: 7020073, pp. 1-4, Feb. 22, 2000.
NCBI database Accession Nos. AAH01628 (protein) & BC001628 (nucleic acid), GI: 12804442, pp. 1-4, Jul. 12, 2001.
Database EM—HUM ′Online !, Database Accession No. AK000164, pp. 1-2, XP-002259870, “Homo sapienscDNA FLJ20157 FIS, Clone COL08833”, Feb. 22, 2000.
Moreira, M.D.C., et al., American Journal of Human Genetics, 68(2): 501-508, XP-002259869, “Homozygosity Mapping of Portuguese and Japanese Forms of Ataxia-Oculomotor Apraxia to 9p 13, and Evidence for Genetic Heterogeneity”, Feb. 2001.
Date, H., et al., Nature Genetics, 29(2): 184-188, XP-001172475, “Early-Onset Ataxia With Ocular Motor Apraxia and Hypoalbuminemia is Caused by Mutations in a New Hit Superfamily Gene”, Oct. 2001.
Moreira, M.D.C., et al., Nature Genetics, 29(2): 189-193, XP-001172474, “The Gene Mutated in Ataxia-Ocular Apraxia 1 Encodes The New Hit/Zn-Finger Protein Aprataxin”, Oct. 2001.
Dynal Catalog. Biomagnetic Techniques in Molecular Biology, 1998. pp. 8-9.
Hirano, et al., “Novel Splice Variants Increase Molecular Diversity of Aprataxin, the Gene Responsible for Early-Onset Ataxia with Ocular Motor Apraxia and Hypoalbuminemia,” Neuroscience Letters, 366: 120-125 (2004).
Osada, et al., “Macaca Fascicularis Brain cDNA,” Genbank Accession No. AB056422, Mar. 1, 2001.

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