Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-09-19
1999-01-12
Carlson, Karen Cochrane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 691, A01N 3718, A61K 3700, C12P 2106
Patent
active
058589678
ABSTRACT:
Methods for identifying factors that regulate appetite are disclosed. Preferably, the methods feature determinination of decreased food consumption in selected recipient mammals following administration of a test sample. A product having appetite suppressing activity is also described. In addition, methods for reducing food consumption in a mammal, featuring administration of a pharmaceutical composition comprising a representative appetite suppression factor, are disclosed.
REFERENCES:
patent: 4197319 (1980-04-01), Betz et al.
patent: 4489059 (1984-12-01), Rossini et al.
patent: 4491578 (1985-01-01), Peiken
patent: 4588685 (1986-05-01), Knoll et al.
patent: 4613586 (1986-09-01), Barchas et al.
patent: 5013722 (1991-05-01), Danho et al.
patent: 5169852 (1992-12-01), Barchas et al.
patent: 5378816 (1995-01-01), Pungor et al.
patent: 5552524 (1996-09-01), Basinski et al.
Murakami et al., Biochemical and Biophysical Research Communications 209(3):944-952, 1995.
Hulsey et al., Physiology & Behavior 52: 1141-1149, 1992.
Ako et al., Life Sciences 42: 877-888, 1988.
Nagy, Pharmacology Biochemistry and Behavior 48(1): 17-22, 1994.
Sniderman et al., Ann. Med. 26: 389-393, 1994.
Kidwai et al., Mol. Cell. Biol. 91: 117-122, 1989.
Bellinger et al., Pharmacology Biochemistry and Behavior 47(3): 659-666, 1994.
Zhang et al., Nature 372: 425-432, 1994.
Hutson et al., Clin. Res. 40: 60A, 1992.
Weigle, The FASEB Journal 8: 302-310, 1994.
Bowie et al., "Deciphering the message in protein sequences: tolerance to amino acid substitions" Science (1990) 247:1306-1310.
Callard et al., The Cytokine FactsBook, Academic Press, London, pp. 31 and 139.
Campfield et al., "Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks" Science (1995) 269: 546-549.
Chen, "A single intracerebroventricular injection of dexamethasone elevates food intake and plasma insulin and depresses metabolic rates in adrenalectomized obese (ob/ob) mice" J. Nutrition(1995).
Considine et al., "Evidence against either a premature stop codon or the absence of abese gene mRNA in human obesity" J. Clin. Invest. (1995) 95:2986-2988.
Dubuc, "Effects of limited food intake on the obese-hyperglycemic syndrome" Am. J. Phys. (1976) 230(6):1474-1479.
Friedman et al., "Tackling a weighty problem" Cell (1992) 69:217-220.
Halaas et al., "Weight-reducing effects of the plasma protein encoded by the obese gene" Science (1995) 269:543-546.
Harlow et al., Antibodies, A Laboratory Manual, Cold Spring Harbor Laboratory, 1988, pp. 53-137.
King, "Lipostatic control of body weight: Evidence of humoral mediation" Phys. Psych. (1976) 4(4):405-408.
Knoll, "Satietins, .alpha..sub.1 -glycoproteins in human plasma with potent, long-lasting and selective anoretic activity" Med. Res. Rev. (1987) 7:107-144.
Leighton et al., "The effects of the kappa agonist PD-117302 on feeding behavior in obese and lean Zucker rats" Pharm. Biochem. Behav. (1988) 31:425-429.
Maniatis et al., Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, 1982, pp. 403-433.
Ngo et al., The Protein Folding Problem and Tertiary Structure Pediction, Mez et al., eds., Birkhauser, Boston , 1994, pp. 491-495.
Pelleymounter et al., "Effects of the obese gene product on bodyweight regulation in ob/ob mice" Science (1995) 269:540-543.
Sambrook et al., Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, 1989, pp. 18.77-18.80.
Williamson et al., "Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family" Biochem. (1994) 33:11745-11759.
Zsigmond et al., "Proteolytic degradation of HDL on the fat cell surface is nutritionally regulated" Biochem. Cell. Bio. (1989) 67:428-433.
Forstrom John W.
Kuijper Joseph L.
Weigle David S.
Carlson Karen Cochrane
University of Washington
ZymoGenetics Inc.
LandOfFree
Appetite supression factor and related methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Appetite supression factor and related methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Appetite supression factor and related methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1515879