Apparatus, methods, and computer program products for...

Surgery – Diagnostic testing – Cardiovascular

Reexamination Certificate

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C600S515000

Reexamination Certificate

active

07047067

ABSTRACT:
Methods, systems, and computer program products can be provided for evaluating a risk of the occurrence of cardiac arrhythmias in a heart. The system can include at least one sensing electrode and a controller. The sensing electrode can be configured to sense electrical signals from a heart over a range of heart rates. The controller can be configured to determine values of a at least one restitution property of the heart from the sensed electrical signals and to evaluate the risk of the occurrence of cardiac arrhythmias from the determine values of the at least one restitution property.

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patent: 6370431 (2002-04-01), Stoop et al.
Weiss et al., “Chaos and the Transition to Ventricular Fibrillation, A New Approach to Antiarrhythmic Drug Evaluation,” Circulation (1999) 99:2819-2826.
Riccio et al., “Electrical Restitution and Spatiotemporal Organization During Ventricular Fibrillation,” Circulation Research (1999) 84:955-963.
Garfinkel et al., “Preventing ventricular fibrillation by flattening cardiac restitution,” PNAS (2000) 97 (11):6061-6066.
Millar et al., “Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions,” Circulation (1985) 6:1372-1379.

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