Apparatus for time-resolved photography of fluorescence

Details Apparatus for time-resolved photography of fluorescence Apparatus for time-resolved photography of fluorescence

1988-09-26

1990-09-04

Hannaher, Constantine

Radiant energy

Luminophor irradiation

2504591, 378 45, G03B 1504, G03B 4208, G03C 504

Patent

active

049547143

ABSTRACT:
A time-resolved photographic analysis device is capable of analyzing for the presence of fluorescent radiation, particularly in a diagnostic sample. The apparatus comprises a light source for emitting exciting pulses as directed onto the sample. A camera is provided which is focused on the sample with the camera continually exposed to the sample. A chopper device is used in conjunction with the camera to prevent exposure of the photographic film in the camera to background fluorescence generated by miscellaneous components in the sample. Fluorescent labels, if present in the sample, are designed to fluoresce over considerably longer periods than the background fluorescence. A device is provided to coordinate the operation of the chopper device with the rate of flashing of the light source to ensure that the photographic film is only exposed to fluorescent radiation which would be generated by a fluorescent label in the sample being analyzed.

REFERENCES:
patent: 4058732 (1977-11-01), Wieder
patent: 4101221 (1978-07-01), Schunck et al.
patent: 4105333 (1978-08-01), Kaule et al.
patent: 4198567 (1980-04-01), Eneroth
patent: 4336459 (1982-06-01), Fay
patent: 4542290 (1985-09-01), Tan et al.
patent: 4612660 (1986-09-01), Huang
"Two Chopper Technique for Measuring Fluorescence Lifetimes", K. A. Ingersoll, Applied Optics, vol. 15, No. 1, Jan. 76.

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