Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1998-01-05
2000-10-03
Chin, Christopher L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
604 4, 604 5, 604 6, 604 82, 604 85, 422 70, 422 71, 422 59, 436541, 436547, 436548, 530228, 2041824, 204417, G01N 33533
Patent
active
061275271
ABSTRACT:
The present invention relates to the field of site directed therapy. More specifically it relates to site directed radio therapy. It provides a method for production of radioimmuno conjugates and an apparatus for radioimmuno therapy. The method, conjugates and apparatus can be practicalized without the need for radioactive shielding and/or airtight facilities. Without these restrictions the invention provides a simple and efficient means of therapy at the bed-side of the patient.
REFERENCES:
patent: 4001387 (1977-01-01), Barak et al.
patent: 4296785 (1981-10-01), Vitello et al.
patent: 4305922 (1981-12-01), Rhodes et al.
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4663129 (1987-05-01), Achter et al.
patent: 4732864 (1988-03-01), Tolman et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4828991 (1989-05-01), Hanna et al.
patent: 4833329 (1989-05-01), Quint et al.
patent: 4871352 (1989-10-01), Tran et al.
patent: 4923985 (1990-05-01), Gansow et al.
patent: 5246691 (1993-09-01), Geerlings et al.
patent: 5355394 (1994-10-01), van Geel et al.
patent: 5428154 (1995-06-01), Gansow et al.
patent: 5641471 (1997-06-01), Geerlings
DeNardo et al., American Association of Cancer Research, 50:1014s-1016s 1990.
Lambrecht et al., Radiochimica Acta 34, 9-24 (1983).
Spitsyn & Mikheev, Atomic Energy Review, 9:4:778, 1971.
Riechmann et al., Nature 332, 323-327, 1988.
Scheinberg et al., Monoclonal Antibodies Drug Dev., Jacob Abel Symp. for Drug Dev. . 1982, pp. 159-171.
Brown, Intl. J. of Radiation Applications and Instruments, 37:8:789-798, 1986.
Delikan Health Physics, 35:1:21-24, 1978.
Brechbeil et al., J. Chem. Soc. Perkin I, 9:1173-1178, 1992.
D.S. Wilbur, "Potential use of a .alpha.-emitting radionuclides in the treatment of cancer," Antibody, Immunoconjugates, and Radiopharmaceuticals, 4:1 1991, pp. 85-97, Mary Ann Liebert, Inc.
T. Mitsugashira et al., "Preparation of traces for actinum, thorium, proactinium and uranium," SPEY, Min. Educ. Sci. & Cult., Tokyo, 9, 1984 pp. 111-116.
S. Suzuki, "Solution chemistry of light actinude elements," Japan-US Seminar on Torium fuel reactors-Proceedings, Nara, Japan, Oct. 18-22, 1982 (Tokyo, 1985) pp. 137-143.
S. Mirzadeh et al., "Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(-4Isothiocyanatobenzyl)diethylenetriaminepentaacetic Acid Ligends to Immunoglobulin," Bioconjugate Chem., Vo. 1, 1990, pp. 59-65.
D.R. Fischer, "Alpha-Particle Emitters in Medicine," Proceedings of a symposium held at Loews L'Enfant Plaza Hotel, Washington D.C., Sep. 21 and Sep. 22, 1989, pp. 194-214.
H. Zwierzina, "Practical Aspects of Cytokine Therapy," Stem Cells, 1993, 11:144-153.
R.W. Kozak et al. "Radionuclide-conjugated monoclonal antibodies: a synthesis of immunology, inorganic chemistry amd nuclear science," TIBTECH, 4(10):259-264, 1986.
D.M. Goldenberg, "Targeting of Cancer with Radiolabeled Antibodies," Vistas in Immunopathology, 112:580-587, 1988.
M.E. Osband et al., "Problems in the investigational study and clinical use of cancer immunotherapy," Immunology Today, 11:6:193-195 (1990).
Akzo Nobel N.V.
Blackstone William M.
Chin Christopher L.
Nguyen Bao-Thuy L.
LandOfFree
Apparatus for the therapeutic use of .sup.213 Bi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for the therapeutic use of .sup.213 Bi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for the therapeutic use of .sup.213 Bi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-197125