Apparatus for the synthesis of saccharide compositions

Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 97, 435819, C12M 140

Patent

active

052886379

ABSTRACT:
An apparatus for a glycosyltransferase-catalyzed synthesis of a tetrasaccharide composition of the formula gal-glcNAc-gal-B-1,4-glc from saccharide units and an acceptor moiety. The apparatus has a reactor, an inlet, an outlet, and contains two glycosyltransferases; an N-acetyl glucosaminyltransferase and a galactosyltransferase.

REFERENCES:
patent: 3666627 (1972-05-01), Messing
patent: 3930950 (1976-01-01), Royer
patent: 4184917 (1980-01-01), Dorner et al.
patent: 4219571 (1980-08-01), Miyake
patent: 4250262 (1981-02-01), Taubman et al.
patent: 4261976 (1981-04-01), Isselbacher et al.
patent: 4386158 (1983-05-01), Shimizu et al.
patent: 4451566 (1984-05-01), Spencer
patent: 4537763 (1985-08-01), Miyake et al.
patent: 4557927 (1985-12-01), Miyake et al.
patent: 4563445 (1986-01-01), Feizi et al.
patent: 4569909 (1986-02-01), Seno et al.
patent: 4590160 (1986-05-01), Nishihashi et al.
patent: 4617269 (1986-10-01), Rathbone et al.
patent: 4621137 (1986-11-01), Miyake et al.
patent: 4693974 (1987-09-01), Schwengers et al.
patent: 4770994 (1988-09-01), Rittenhouse
patent: 4849356 (1989-07-01), Van Dooren et al.
patent: 4918009 (1990-04-01), Nilsson
patent: 4925796 (1990-05-01), Bergh et al.
patent: 5047335 (1991-09-01), Paulson et al.
Rosevear et al, Synthesis & Solution Conformation of the Type 2 Blood Group Oligosaccharide .alpha.LFus (1-2).beta. D Gal (1.fwdarw.4) B DGlcNAC, Biochemistry (1982) 21, 1421-1431.
Kirth-Othmer, Encyclopedia of Chemical Technology vol. 9 (1980) pp. 148-172.
Parodi et al, Biomedicine 28, (1978) pp. 9-13.
Rajan et al., J. Biological Chem., vol. 264, No. 19, pp. 11158-11167 (1989).
Weinstein et al., J. of Biological Chem., vol. 257, No. 22, pp. 13835-13844(1982).
Ernst, et al., J. of Biological Chem., vol. 264, No. 6, pp. 3436-3447(1989).
R. D. Larsen, et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 8227-8231, (Nov. 1989).
1988 FASEB Abstract Form (1p.)w. 3 Abstracts Submitted to UCLA Glycobiology Symposium (3 pp.).
Phil.Bus.J., (Dec. 9-15, 1991) 2 pp. Michael W. Armstrong.
Chemical Abstracts, vol. 94, No. 15, issued Apr. 13, 1981, Imam et al., "Isolation and Characterization of a major glycoprotein from milk-fat-globule membrane of human breast milk", see p. 229, columns 1 and 2, Abstract No. 116282p, Biochemistry Journal, 193(1), 47-54.
Chemical Abstracts, vol. 91, No. 13, issued Sep. 24, 1979, Chatterjee, et al., "Glycosyltransferase and glycosidase activities in ovarian cancer," see p. 446, column 1, Abstract No. 1063004, Cancer Res., 36(6,PT.1), 1943-51.
Chemical Abstracts, vol. 109, No. 17, issued Oct. 24, 1988, Krivan et al., "Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc .beta.1-4 Gal found in some glycolipids", see p. 421, column 2, Abstract No. 146217S, Proc. Natl. Acad. Sci. U.S.A., 85(16), pp. 6157-6.
Biochemistry, vol. 21, No. 6, pp. 1421-1431, Mar. 16, 1982, P. R. Rosevear, et al., "Synthesis And Solution Conformation Of the Type 2 Blood Group Oligosaccharide ALPHAFuC(1-2) BETADGal(1-4)BETADG1cNAc".
Carbohydrate Research, vol. 137, pp. 39-62, Mar. 29, 1985, H. Paulsen, et al., "Synthese Der Tetra-UND Trisaccharid-Sequenzen Von Asialo-Gm1 Und-Gm2 Lenkung Der Regioselektivitat Der Glycosidierung Von Lactose".
The Journal of Biological Chemistry, vol. 265, No. 9, pp. 4859-4862, Mar. 25, 1990, H. Kitagawa, et al., "Occurance of the Tetra-And Pentasaccharides With The Sialyl-LEa Structure In Human Milk".
Chemical Abstracts, vol. 74, No. 7, p. 167, No. 29979q, Feb. 15, 1971, H. Takizawa, et al., "Blood Group Substances From Human Erythrocytes. II. Structural Analysis By Methylation of Blood Group-Active Oligosaccharides".
Chemical Abstracts, vol. 114, No. 9, issued Mar. 4, 1991, De Stafano et al., "Analysis of Pneumocystis carinii cyst wall. II. Sugar Composition," see pp. 389 and 390, columns 2 and 1 abstract No. 78313w, J. Protozool., 37(5), 436-41.
"Weak-affinity Chromatography"; D. Zopf and S. Ohlson; Nature; vol. 346, No. 6279, pp. 87-88; Jul., 1990.
"Glycotechnology Drugs Begin To Emerge from the Lab"; Stu Borman; Chemical & Engineering News; Jun. 28, 1993; pp. 27-34.
"Patent Grants Broad Protection To Enzymatic Carbohydrate Synthesis"; Stu Borman; Chemical & Engineering News; Mar. 29, 1993; pp. 24-27.
"Race Is On To Develop Sugar-Based Anti-inflammatory, Antitumor Drugs"; Stu Borman; Chemical & Engineering News; Dec. 7, 1992; pp. 25-28.
"Enzyme-Catalyzed Oligosaccharide Synthesis"; Yoshitaka Ichikawa, Gary C. Look, and Chi-Huey Wong; Analytical Biochemistry 202; 1992; pp. 215-238.
"Novikoff Ascites Tumor Cells Contain N-Actelyllactosamide .beta.1.fwdarw.3 and .beta.1.fwdarw.6 N-Acetylgucosaminyltransferase Activity"; van den Eijnden, et al; The Journal Of Biological Chemistry; vol. 258, No. 6, Mar. 25, 1983; pp. 3435-3437.
"Abbott Invests $17M in Neose"; Jennifer Van Brunt; Bioworld Today; vol. 4, No. 30, p. 1; Feb. 12, 1993.
"A Drug Collaboration"; Philadelphia Enquirer; Feb. 12, 1993.
Toone et al., Tetrahedron, vol. 45, No. 17, pp. 5365-5422 (1989).
Zehavi et al., Carbohydrate Research, 124, pp. 23-34 (1983).
Palcic et al., Carbohydrate Research, 190, pp. 1-11 (1989).
Nilsson, Immunochemistry, vol. 110, Abstr. 110:6111y, p. 581 (1989).
Thiem et al., Angew. Chem. Int. Ed. Engl. 25, No. 12, pp. 1096-1097 (1986).
Palcic et al., Carbohydrate Research, 159, pp. 315-324 (1987).
Narimatsu et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 4720-4724 (Jul. 1986).
Rosevear et al., Biochemistry, 21, pp. 1421-1431 (1982).
Pollak et al., J. Am. Chem. Soc., vol. 102, No. 20, pp. 6324-6336 (1980).
Wong, Science, vol. 244, pp. 1145-1152 (Jun. 9, 1989).
Nunez et al., Biochemistry, vol. 19, No. 3, pp. 489-495 (1980).
Zehavi et al., Carbohydrate Research, 133, pp. 339-342 (1984).
Zehavi et al., Carbohydrate Research, 128, pp. 160-164 (1984).
Sadler et al., Methods in Enzymology, vol. 83, pp. 458-493 (1982).
Cote et al., Chemical Abstracts, vol. 113, Abstract No. 113:187372q (1990).
Kitahata, Chemical Abstracts, vol. 111, Abst. No. 111:93061u, p. 355 (1989).
Kitahata, Chemical Abstracts, vol. 113, Abst. No. 113:170336h, p. 567 (1990).
Katsumi et al., Chemical Abstracts, vol. 111, Abst. No. 111:152000y, p. 565 (1989).
Auge et al., Carbohydrate Research, 151, pp. 147-156 (1986).
Auge et al., Carbohydrate Research, 200, pp. 257-268 (1990).
Auge et al., Carbohydrate Research, 193, pp. 288-293 (1989).
Sabesan et al., J. Am. Chem. Soc., vol. 108, No. 8, pp. 2068-2080 (1986).
Closs et al., J. Org. Chem., vol. 47, No. 27, pp. 5416-5418 (1982).
Sheares et al., J. of Biological Chem., vol. 258, No. 16, pp. 9893-9898 (1983).
van den Eijnden et al., J. Biol. Chem., vol. 263, No. 25, pp. 12461-12471 (1988).
Creeger et al., J. Biol. Chem., vol. 254, No. 3, pp. 804-810 (1979).
Appert et al., Biochemical and Biophysical Research Communications., vol. 139, No. 1, pp. 163-168 (Aug. 29, 1986).
Cartron et al., FEBS LETTERS, vol. 67, No. 2, pp. 143-148 (Aug. 1976).
Elices et al., Arch. of Biochemistry and Biophysics, vol. 254, No. 1, pp. 329-340 (Apr. 1987).
Suganuma et al., J. Biochem., vol. 102, No. 3, pp. 665-671 (1987).
Demers et al., J. of Applied Biochemistry, vol. 7, pp. 122-125 (1985).
Barker et al., J. of Biol. Chem., vol. 247, No. 22, pp. 7135-7147 (1972).
Furukawa et al., Biochem. J., vol. 227, pp. 573-582 (1985).
Roth et al., Experimental Cell Research, vol. 143, pp. 217-225 (1983).
Benau et al., J. of Histochemistry and Cytochemistry, vol. 38, No. 1, pp. 23-30 (1990).
Thomas Schaal et al., Glycoconjugate Journal, vol. 7, No. 5, p. 475 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Apparatus for the synthesis of saccharide compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apparatus for the synthesis of saccharide compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for the synthesis of saccharide compositions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-170503

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.