Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2004-05-27
2009-06-09
Weber, Jon P (Department: 1657)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
Reexamination Certificate
active
07544503
ABSTRACT:
The present invention relates to a spectroscopic apparatus for non-invasive in vivo analysis of blood and to a corresponding analysis method, in particular for direct determination of the pH value of the blood. From a Raman signal detected from an excited target region containing blood at least one predetermined pH sensitive signal portion is determined, from which the pH value of the blood in the target region by use of a relationship between pH value and one or more band parameters of pH sensitive vibrations of at least one molecule or part of a molecule present in blood, in particular heme vibrations of hemoglobin, is determined.
REFERENCES:
patent: 5355880 (1994-10-01), Thomas et al.
patent: 5885212 (1999-03-01), Scharlack
patent: 6205354 (2001-03-01), Gellermann et al.
patent: 2002/0156380 (2002-10-01), Feld et al.
patent: WO 99/40411 (1999-08-01), None
patent: WO 02/07585 (2002-01-01), None
patent: WO 02/054936 (2002-07-01), None
patent: WO 02/057759 (2002-07-01), None
Alam et al. Applied Spectroscopy 1998;52(3):393-399.
Pilotto et al. Lasers Med Sci 2001;16:2-9.
Bauer et al. “In vivo confocal Raman spectroscopy of the human cornea”, Cornea, 1999, 18(4):483-488.
Alam, M.K., et al.; Characterization of pH Variation in Lysed Blood by Near-Infrared Spectroscopy; 1998; Applied Spectroscopy; 52:393-399.
Caspers, P.J., et al.; In Vivo Confocal Raman Microspectroscopy of the Skin: Noninvasive Determination of Molecular . . . ; 2001; Soc. For Invest. Derm.; 116(3)434-442.
Lucassen Gerhardus Wilhelmus
Puppels Gerwin Jan
Koninklijke Philips Electronics , N.V.
Shen Bin
Weber Jon P
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