Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus
Patent
1996-02-05
1998-12-01
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Differentiated tissue perfusion or preservation apparatus
4352891, 4352972, 4352975, 4352991, 4352931, C12M 300
Patent
active
058437665
ABSTRACT:
A tissue culture chamber is disclosed. The chamber is a casing that provides for growth of three-dimensional tissue, and more specifically for the growth of skin tissue, that can be grown, preserved in frozen form, and shipped to the end user in the same aseptic container. The tissue culture chamber includes a casing comprising a substrate within the casing designed to facilitate three-dimensional tissue growth on the surface of the substrate. The casing includes an inlet and an outlet port which assist the inflow and outflow of media. The casing also includes at least one flow distributor. In one embodiment, the flow distributor is a baffle, which is used to distribute the flow of the media within the chamber to create a continuous, uniform piece of three-dimensional tissue. In a second embodiment, the flow distributor is a combination of deflector plates, distribution channels, and a flow channel. In each embodiment, the casing further includes a seal so as to ensure an aseptic environment inside the chamber during tissue growth and storage.
REFERENCES:
patent: 2784843 (1957-03-01), Braunlich
patent: 3734851 (1973-05-01), Matsumura
patent: 3952577 (1976-04-01), Hayes et al.
patent: 4201845 (1980-05-01), Feder et al.
patent: 4417861 (1983-11-01), Tolbert
patent: 4639422 (1987-01-01), Geimer et al.
patent: 4681853 (1987-07-01), Hardy et al.
patent: 4846970 (1989-07-01), Bertelsen et al.
patent: 4944877 (1990-07-01), Maples
patent: 4988623 (1991-01-01), Schwarz et al.
patent: 5026650 (1991-06-01), Schwarz et al.
patent: 5043260 (1991-08-01), Jauregul
patent: 5068195 (1991-11-01), Howell et al.
patent: 5081035 (1992-01-01), Halberstadt et al.
patent: 5153131 (1992-10-01), Wolf et al.
patent: 5153132 (1992-10-01), Goodwin et al.
patent: 5153133 (1992-10-01), Schwarz et al.
patent: 5155034 (1992-10-01), Wolf et al.
patent: 5155035 (1992-10-01), Schwarz et al.
patent: 5230693 (1993-07-01), Williams et al.
patent: 5240854 (1993-08-01), Berry et al.
patent: 5266480 (1993-11-01), Naughton et al.
patent: 5308764 (1994-05-01), Goodwin et al.
patent: 5376548 (1994-12-01), Matsuo et al.
patent: 5417576 (1995-05-01), Hill
Atkinson et al.; Biochemical Engineering and Biotechnology Handbook; pp. 476-487 (1991).
Halberstadt et al., "The In Vitro Growth of a Three-Dimensional Human Dermal Replacement Using a Single-Pass Perfusion System," Biotechnology and Bioengineering 43:740-746 (1994).
Applegate Dawn Orton
Applegate Mark
Baumgartner Mark
Bennett John W.
Danssaert John
Advanced Tissue Sciences Inc.
Beisner William H.
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