Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-09-02
1998-11-17
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
6048911, 222 63, 222639, 222626, 222271, 222311, 222333, 222410, 222493, 222525, 424400, 424443, A61K 900, B65D 8300
Patent
active
058372768
ABSTRACT:
The invention features an implantable device for the automatic delivery of an active ingredient according to an adjustable delivery profile. The device includes a housing; a reservoir operatively connected to the housing and arranged to store an elongate solid composition including the active ingredient, such as a filament of tape; an actuator arranged within the housing to move the solid composition from the reservoir to a transit assembly, providing a water-tight seal wherein the solid composition exits the housing at the transit assembly; a controller that acts on the actuator to adjust movement of the solid composition out of the housing according to the adjustable delivery profile; and a power source arranged to provide energy to the actuator and the controller. The solid composition can be an elongate, solid composition comprising a drug, and up to 90% of a carrier, wherein the composition has a cross-section of less than 0.5 mm, and wherein the drug and the carrier are selected and compounded in a proportion such that the drug is immediately released from the carrier upon contact with a liquid.
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DELAB
Webman Edward J.
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