Liquid purification or separation – Filter – Within flow line or flow line connected close casing
Patent
1988-12-21
1990-06-26
Jones, W. Gary
Liquid purification or separation
Filter
Within flow line or flow line connected close casing
210435, 210491, 210492, 210505, B01D 2412
Patent
active
049369938
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to an apparatus for the separation of blood components. More particularly, it relates to an apparatus for the separation of blood components, specifically for the removal of white blood cells and blood platelets from blood.
BACKGROUND ART
Heretofore in the therapy by blood transfusion, more often than not whole-blood preparations of red blood cell preparations have been used. These preparations, however, inevitably contain the white blood cell antibody and the blood platelet antibody and pose as a problem the possibility of the antibodies giving rise to secondary reactions. As a solution to this problem, the practice of removing of white blood cells and blood platelets from the whole-blood preparations and the red blood cell preparations has been heretofore in vogue. As means for the separation of blood components, specifically for the removal of white blood cells and blood platelets from the whole blood or from the red blood component, there has been proposed an apparatus which is obtained by filling a housing with defatted and bleached Egyptian cotton in uniform density (Japanese Patent Publication NO. SHO 55(1980)-23,805).
When an apparatus of this nature is used, however, the degree with which the removal of white blood cells and blood platelets is attained hinges on he density of packing of the Egyptian cotton and the efficiency of this removal is improved but the speed of passage of blood through aggregate of cotton is lowered and the time required for the treatment is lengthened in proportion as the density of packing is increased. Conversely, the speed of passage of blood is heightened but the efficiency of removal is lowered in proportion as the density of packing is lowered. Thus, the apparatus is hardly practicable.
An object of this invention, therefore, is to provide a novel apparatus for the removal of blood components.
Another object of this invention is to provide an apparatus for the separation of blood components, which permits quick passage of blood under treatment and warrants a reduction in the time for the treatment at no sacrifice of the efficiency of removal of white blood cells and blood platelets.
DISCLOSURE OF THE INVENTION
The objects described above are accomplished by an apparatus for the separation of blood components, which comprises a tubular housing provided at one end thereof with a blood inlet and at the other end thereof with a blood outlet and a layer of aggregate of fibers capable of sequestering white blood cells and blood platelets packed in the housing, the layer of aggregate of fibers comprising of a blood inlet side layer having a bulk density of not less than 0.16 g/cm.sup.3 and less than 0.21 g /cm.sup.3 and a blood outlet side layer having a bulk density of not less than 0.21 g/cm.sup.3 and not more than 0.23 g/cm.sup.3 and being packed at a density in the range of 0.04 to 0.09 g per ml of the flow volume of blood under treatment.
This invention also concerns an apparatus for the separation of blood components, wherein the fibers packed in the form of a layer of aggregate are single fibers. This invention further concerns an apparatus for the removal of blood components, wherein the fibers are natural fibers such as of cotton or synthetic fibers such as of polyester, polyacrlylonitrile, polyamide, or cellulose acetate. This invention concerns an apparatus for the separation of blood components, wherein the fibers are defatted and bleached fibers of Egyptian cotton. This invention also concerns an apparatus for the separation of blood components, wherein the blood inlet side layer comprises a first layer having a blood inlet side bulk density of not less than 0.16 g/cm.sup.3 and less than 0.19 g/cm.sup.3 and a second layer having a blood outlet side bulk density of not less than 0.19 g/cm.sup.3 and less than 0.21 g/cm.sup.3.
BRIEF DESCRIPTION OF DRAWINGS
FIG. 1 is a partially sectioned side view of a typical apparatus for the separation of blood components as one embodiment of the present invention,
FIG. 2 is a c
REFERENCES:
patent: 4130642 (1978-12-01), Kikugawa
patent: 4246107 (1981-01-01), Takenaka
patent: 4330410 (1982-05-01), Takenaka
patent: 4596657 (1986-06-01), Wisdom
patent: 4701267 (1987-10-01), Watanabe et al.
patent: 4810378 (1989-03-01), Carmen et al.
patent: 4810394 (1989-03-01), Masuda
Jones W. Gary
Terumo Kabushiki Kaisha
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