Apparatus for producing gradient elution in a liquid chromatogra

Details Apparatus for producing gradient elution in a liquid chromatogra Apparatus for producing gradient elution in a liquid chromatogra

1980-01-07

1980-12-16

Adee, John

Liquid purification or separation

Constituent mixture variation responsive

73 611C, 2101982, B01D 1508

Patent

active

042396239

ABSTRACT:
An aparatus for producing gradient elution in a liquid chromatographic system is diclosed. The apparatus comprises variable dosing means for at least two different solvents said dosing means including variable flow resistances for said solvents. A mixing means is provided for mixing said solvents and delivering a solvent mixture which is fed by pump means to a chromatographic column. Density measuring means is provided for measuring the density of said solvent mixture which density is a function of the mixing ratio of said different solvents. Control means responsive to said density measuring means adjust said flow resistances in accordance with a given nominal density curve corresponding to a desired elution gradient.

REFERENCES:
patent: 3917531 (1975-11-01), Magnussen
patent: 3985019 (1976-10-01), Boehme et al.
patent: 4032445 (1977-06-01), Munk
patent: 4066879 (1978-01-01), Leavch
patent: 4128476 (1978-12-01), Rock

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