Apparatus for preparing a solid phase microparticulate compositi

Details Apparatus for preparing a solid phase microparticulate compositi Apparatus for preparing a solid phase microparticulate compositi

1997-09-18

2000-03-28

McKane, Elizabeth

Chemical apparatus and process disinfecting, deodorizing, preser

Physical type apparatus

Means separating or dissolving a material constituent

422260, 3661814, 366247, B01F 716

Patent

active

060427922

ABSTRACT:
Described are controlled, time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to services such as skin, hair and fabric and the environment proximate thereto, where the active and bioactive materials have a calculated log.sub.10 P values of between 1 and 8 (P being the n-octanol-water partition coefficient). Such compositions include the active or bioactive material in single phase, solid solution in a wax or polymer matrix also having coated thereon and/or containing a compatible surfactant. Also described are processes and apparatus for preparing such compositions and processes for using same. Furthermore, certain component(s) of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity.

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Donbrow (editor), Microcapsules and Nanoparticles in Medicine and Pharmacy, published by CRC Press, 1992, Chapter 6, pp. 125-148 and entitled Nanoparticles--Preparation and Applications (by Jorg Kreuter).
Adeyeye and Price, entitled "Development and Evaluation of Sustained-Release Ibuprofen-Wax Microspheres. I. Effect of Formulation Variables on Physical Characteristics", Pharm. Res. (1991), vol. 8, No. 11, pp. 1377-1383.

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