Apparatus for performing capillary electrophoresis

Details Apparatus for performing capillary electrophoresis Apparatus for performing capillary electrophoresis

1993-07-01

1994-11-15

Niebling, John

Chemistry: electrical and wave energy

Apparatus

Coating, forming or etching by sputtering

B01D 6142

Patent

active

053645219

ABSTRACT:
An apparatus for performing capillary electrophoresis comprises a housing (37) to which a sealing and electrode arrangement (36) is fastened and a removable cassette (22) which accommodates a capillary (1) in which electrophoretic separation of a sample takes place when an electric field is applied. When performing an electrophoretic separation, the end of the capillary (1) and a tube-shaped electrode (39) surrounding the capillary (1) dip into a liquid vial containing electrolyte or sample liquid. Liquid is injected into the capillary (1) by applying pressure on the liquid in the vial. An elastomeric seal (40) around the capillary (1) is provided to prevent escaping of the pressure during injection. The end of the capillary (1) depending from the cassette (20) is introduced through a funnel (41) and a central bore in the seal (40). When the cassette (20) is pressed downwards onto the funnel (41), the elastomeric seal (40) is squeezed so that the capillary (1) is sealed off. Since the seal ( 40) is arranged in the housing (37), no sealing is required in the cassette, resulting in a simpler construction of the cassette and facilitating replacement of the capillary in the cassette. (FIG. 4)

REFERENCES:
patent: 4242909 (1981-01-01), Gundelfinger
patent: 4713974 (1987-12-01), Stone
patent: 5019236 (1991-05-01), Young
Characterization and Automation of Sample Introduction Methods for Capillary Zone Electrophoresis: Donald J. Rose, Jr., and James W. Jorgenson; Apr. 1, 1988; pp. 1-7.

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