Chemistry: analytical and immunological testing – Clotting or clotting factor level tests
Patent
1997-04-30
2000-01-04
Warden, Jill
Chemistry: analytical and immunological testing
Clotting or clotting factor level tests
436 10, 436 18, 436 63, 422 73, 435 4, 435 13, G01N 3316
Patent
active
060109114
ABSTRACT:
An apparatus and method for performing activated clotting time tests, including their use for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells. Each of the cells comprises a heparin-inactivating agent, an anticoagulant agent, and a clotting reagent. At least one of the test cells further comprises a platelet activating agent. The clotting time is determined for each of the aliquot portions, and the relative clotting times of the aliquot portions in the cells are determinative of the platelet functionality of the sample. The method comprises the steps of combining a heparin-inactivating agent, an anticoagulant agent, a clotting reagent, a platelet activating agent, and the sample of blood to be tested to form a test mixture. The platelets of the sample are activated by agitating the test mixture, and the activated clotting time test is terminated upon detecting a predetermined change in a property of the test mixture. The activated clotting time of the sample of blood is calculated based on the elapsed time.
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Baugh Robert F.
Lane Carole G.
Wilson Adrian C.
Carrillo S.
Medtronic Inc.
Petersen Steven C.
Warden Jill
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