Liquid purification or separation – With means to add treating material – Chromatography
Patent
1992-03-02
1993-04-20
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
210656, B01D 1508
Patent
active
052039927
ABSTRACT:
An apparatus for optimizing the liquid chromatographic separation of a sample comprises means for performing liquid chromatographic separations at selectable values of an optimization parameter, such as the composition of the mobile phase. Based upon measured chromatographic data of the sample and upon a mathematical model, the retention behavior of the sample as a function of the optimization parameter is derived by data processing means and displayed on a display means. An input means permits the chromatographer to select from the displayed retention behavior a desired value of the optimization parameter. In response to such a selection, the resulting chromatogram for this value is calculated and displayed. By means of the displayed retention behavior and the corresponding chromatograms, the chromatographer can quickly locate a value of the optimization parameter for which optimal results can be expected. Then, a chromatographic separation of the sample is performed with the selected value. The chromatographic data obtained in that separation are used to refine the mathematical model from which a new retention behavior is derived. The process is iterated until a desired optimum is achieved.
REFERENCES:
patent: 3701609 (1972-10-01), Bailey
patent: 4063077 (1977-12-01), Wright
patent: 4066879 (1978-01-01), Leaver
patent: 4116046 (1978-09-01), Stein
patent: 4237422 (1980-12-01), Lenhardt
patent: 4357668 (1982-11-01), Schwartz
patent: 4364263 (1982-12-01), Sankoorikal
patent: 4579663 (1986-04-01), Poile
patent: 4592842 (1986-06-01), Tomlinson
patent: 4595495 (1986-06-01), Yotam
patent: 4595496 (1986-06-01), Carson
patent: 4719017 (1988-01-01), Uchino
patent: 4762617 (1988-08-01), Stevens
patent: 4802981 (1989-02-01), Kenney
patent: 4886590 (1989-12-01), Tittle
patent: 4927532 (1990-05-01), Pospisil
patent: 4969993 (1990-11-01), Nash
Annino, R. & Villalobos, R., "A Computer Aided Optimization Program Including Stationary Phase Selection and Optimized Analysis Conditions", Advances in Instrumentation, 1986, 41, 383-402.
Snyder, L. R., et al., "High-performance liquid chromatographic method-development using computer simulation", TrAC, 1987, 6(5), 106-111.
Berridge, J. C., "Using a Microprocessor in high performance liquid chromatography", Microprocessors and Microsystems, 1983, 7(1), 19-23.
Drouen, A. C. J. H., et al., "An Improved Optimization Procedure for the Selection of Mixed Mobile Phases in Reversed Phase Liquid chromatography", Chromatographia, 1982, 16, 48-52.
Hewlett--Packard Company
Therkorn Ernest G.
LandOfFree
Apparatus for optimizing the liquid chromatographic separation o does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for optimizing the liquid chromatographic separation o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for optimizing the liquid chromatographic separation o will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1524016