Radiant energy – Automatic/serial detection of similar sources
Patent
1990-04-11
1991-08-13
Fields, Carolyn E.
Radiant energy
Automatic/serial detection of similar sources
250364, G01T 1204
Patent
active
050398601
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
Multi-well sample plates which comprise several separate sample wells are widely used as test plates for in vitro analysis. Said plates can be produced for example by vacuum thermoforming (deep drawing) from a transparent plastic sheet and they have for example eight rows of wells arranged in twelve columns. These plates can be used especially for preparing typically low energy beta radiation emitting liquid scintillation samples. Unfortunately, these samples must first be transferred into liquid scintillation counting vials, because existing liquid scintillation counters cannot count samples directly from this kind of multi-well sample plates.
SUMMARY OF THE INVENTION
The present invention shows a new apparatus which counts one or several liquid scintillation or corresponding samples at a time directly from the multi-well sample plates which comprise several separate sample wells.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGS. 1a and 1b show vertical sections of the counting apparatus under two different conditions.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In FIG. 1a a sample plate (10), which has several sample wells (11) is placed manually or automatically in a position where a liquid scintillation sample (16), which is in the sample well (11), can be counted. In order to count one or several samples (16), which are in said sample wells (11), at a time, the apparatus has one or several detectors that consists of two photomultiplier tube assemblies (14a, 14b) which work in coincidence and are situated on the top and bottom of said sample plate (10).
The lower photomultiplier tube assembly (14a) is provided with a tube (12). The inner diameter of this tube (12) is equal to or larger than the maximum outer diameter of the sample wells (11).
The apparatus has a moving mechanism, which is not shown here, by which said lower photomultiplier tube assembly (14a) provided with said tube (12) can be moved to up or down positions.
In FIG. 1a said lower photomultiplier tube assembly (14a) provided with said tube (12) is in the down position in order to allow free horizontal movement of said sample plate (10). In FIG. 1b said lower photomultiplier tube assembly (14a) provided with said tube (12) has been lifted to the up position tightly against said upper photomultiplier tube assembly (14b) in order to form an optically closed compartment around said sample well (11) of the sample plate (10).
In order to guide the light from the liquid scintillation samples (16) located in said sample wells (11) to said photomultiplier tubes (14a, 14b), the inner surfaces (17) of said tube (12) reflects or scatters light.
In order to prevent light from travelling between the sample wells (11) inside the material of the sample plate (10), one or both of the surfaces (18) between the wells (11) of the sample plate (10) are painted black or this region (18) is treated in some other way which prevents light from travelling between the sample wells (11) inside the material of the sample plate (10).
The invention is not confined to the above embodiments alone, but it may show even considerable variation within the scope of the patent claims.
1. An apparatus for counting liquid scintillation samples which comprises sample and being in the form of a cup having an open top, a closed bottom and side walls extending upwardly from said closed bottom to said open top, immediately above the open top of a first sample well (11), first photomultiplier assembly (14b) and which is positionable beneath the closed bottom of said first sample well (11), of said first sample well (11), and guide the light from a liquid scintillation sample that is placed in said first sample well (11) to said photomultiplier tube assemblies.
2. Apparatus according to claim 1 wherein the surfaces of said sample plate that extends between said sample wells are treated to prevent light from travelling between said sample wells via the material of said sample plate.
DESCRIPTION
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In FIG. 1a a sample pla
REFERENCES:
patent: 3924128 (1979-12-01), Frank
patent: 4298796 (1981-11-01), Warner
"McGraw-Hill Dictionary of Scientific and Technical Terms", McGraw-Hill Book Co., N.Y., 1978, p. 916.
Lehtinen Kauko
Sonne Vesa
Yrjonen Tapio
Fields Carolyn E.
Philpitt Fred
Wallac Oy
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