Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1986-06-26
1991-01-01
Warden, Robert J.
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
128637, 128665, 356 39, 356445, 422 58, 422 8209, 422 8208, 435 14, 435 25, 435310, 436 95, 436136, 436138, 436800, 436805, 436904, C12M 134
Patent
active
049817795
ABSTRACT:
A method for monitoring the glucose level in a body fluid uses an apparatus which includes a conjugate of glucose oxidase with a fluorescent dye coated onto an optical fiber in contact with the body fluid, a source of excitation light and a fluorescence emission detector. Glucose is oxidized by oxygen in the body fluid causing a decrease in oxygen concentration at the enzyme. The fluorescent dye is sensitive to oxygen quenching so that, when the oxygen concentration decreases, fluorescence emission increases in direct proportion to the glucose concentration in the fluid.
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Biomedical Technology, "New Blood Glucose Monitoring System from Boehringer Mannheim", vol. 12, No. 11, p. 123, Nov. 1, 1985.
Becton Dickinson and Company
Brown Richard E.
McMahon Timothy M.
Warden Robert J.
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