Apparatus for measuring concentration of light-absorbing...

Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...

Reexamination Certificate

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C600S323000, C600S330000

Reexamination Certificate

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10768680

ABSTRACT:
An apparatus for measuring a concentration of a light-absorbing substance in blood is disclosed. A light emitter emits light beams to irradiate a living tissue, each of the light beams being associated with one wavelength which is absorbed by the blood. A first instrument measures first intensities of the light beams, which are to be incident on the living tissue. A second instrument measures second intensities of the light beams, which are transmitted through the living tissue. A first calculator calculates an attenuation variation ratio, which is a ratio of attenuation variations of the respective light beams due to variation of a volume of the blood caused by pulsation, based on the second intensities of the light beams. A second calculator calculates the concentration based on the first intensities, the second intensities, and the attenuation variation ratio.

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Takehiko Iijima, et al., “Cardiac output and circulating blood volume analysis by pulse dye-densitometry”, Journal of Clinical Monitoring 1997 13: 81-89 (discussed in the specification on p. 1).
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Takasuke Imai, et al., “Measurement of blood concentration of indocyanine green by pulse dye-densitometry-Comparison with the conventional spectrophotometric method”, Journal of Clinical Monitoring 1998, 14: 477-484 (discussed in the specification on p. 1).

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