Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1986-06-16
1989-04-18
Richman, Barry S.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
128691, 356 39, 422110, 436 69, 436 70, G01N 1505
Patent
active
048225681
ABSTRACT:
A whole blood aggregometer of red blood cells (RBC) consists of a transparent tube containing freshly drawn heparinized blood, and a densitometer head which is attached to the tube. The densitometer head consists of a light source and a light detector to monitor changes in optical density of the blood in the tube. The blood in the tube is first subjected to rapid flow with a solenoid, so that the wall shear rate of the blood approximates to 500 s.sup.-1. The shear gives rise to a rapid increase in optical density of the blood due to dispersion of the blood corpuscles. The blood is then brought abruptly to a full stop. After the flow has stopped, the densitometer head reveals a gradual decrease in optical density in association with RBC aggregate formation. The resultant pattern is termed as an "RBC aggregogram". The RBC aggregogram exhibits a quasi-exponential decay in its initial part, which is followed by an asymptotical decrease. A mathematical procedure is employed to calculate the rate constant of the initial decrease from the two values on the RBC aggregogram at 10 s and 20 s. The rate constant k.sub.10 is 0.192+0.028 for feline blood, and 0.129+0.012 for human blood. The RBC aggregation rate varies linearly with the hematocrit below 40%.
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Bartlett Edward D. C.
Johnston Jill
Richman Barry S.
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