Liquid purification or separation – Casing divided by membrane into sections having inlet – Each section having inlet
Patent
1986-11-26
1989-12-05
Richman, Barry S.
Liquid purification or separation
Casing divided by membrane into sections having inlet
Each section having inlet
4352401, B01D 1300, C12N 500
Patent
active
048850870
ABSTRACT:
A mass transfer apparatus and method is based upon use of a mass transfer chamber, such as a hollow fiber membrane bioreactor, with means to change the directional flow therethrough for enhancement of the mass transfer operation. The invention has particular utility in cell growth systems, where the periodic reversal of flow direction of a nutrient stream passed through the bioreactor equalizes dispersion of cell growth through the bioreactor and enhances the transport of metabolic waste from the cells being grown.
REFERENCES:
patent: 3697418 (1972-10-01), Johnson
patent: 4720462 (1988-01-01), Rosenson
patent: 4725548 (1988-02-01), Karrer
"Method and Apparatus for Continuous Cultivation at High Concentration", 61-88872 (A) (Abstract), 9-1986, vol. 10, No. 262 (C-371) (2318).
"Hollow Yarn Type Ultrafiltration", 58-51909 (A) (Abstract), 6-1983, vol. 7, No. 139 (C-171) (1284).
"Continuous Hybridoma Growth and Monoclonal Antibody Production in Hollow Fiber Reactors-Separaters", Altshulter, G. L., et al., Biotechnology and Bioengineering 5-28-86.
Hultquist Steven J.
Richman Barry S.
Wallen T. J.
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