Plastic article or earthenware shaping or treating: apparatus – With interposed non-adhering web or sheet type parting means
Reexamination Certificate
2000-02-09
2001-05-08
Silbaugh, Jan H. (Department: 1732)
Plastic article or earthenware shaping or treating: apparatus
With interposed non-adhering web or sheet type parting means
C425S090000, C425S100000, C425S103000, C425S345000, C425S347000, C425S353000, C425S356000
Reexamination Certificate
active
06227836
ABSTRACT:
BACKGROUND OF THE INVENTION
The present invention relates to a method and an apparatus for manufacturing tablets of moist powder.
Conventionally, tablets are classified into molded tablets and compressed tablets. These two kinds of tablets have been manufactured by different methods. The molded tablets are manufactured by kneading an additive agent such as an excipient or a binder into medical ingredients to form a mixture, adding a solvent such as water, ethanol or the like into the mixture to produce moist powder, and forming the moist powder to have a predetermined shape by molding. There are two methods of forming the moist powder into the tablets, one of which is a thrust-filling method in which the moist powder is forcibly pressed into a die having a certain shape, and the other of which is a die-punching method in which the moist powder is processed into a plate-like material by a rolling machine and a die of a certain shape is pressed against the material for punching. Since the molded tablets exhibit superior solubility and collapsibility when they are taken by a patient, they are manufactured as perlingual tablets and the like.
As an apparatus for manufacturing such molded tablets, an automatic tablet-manufacturing machine produced by Vector Colton in France has been known. This machine produces tablets by filling moist powder into mold cavities formed in a rotary disk, levelling the moist powder to smooth the surface, and pressing and releasing the moist powder out of the mold cavities onto a belt conveyer by ejector pins when they are located concentrically with the mold cavities.
However, tablets produced by the conventional molded tablet manufacturing machine have the same shape as the mold cavities which have a cylindrical shape or a shape with flat upper and lower surfaces. The cross-sectional shape of such tablets is a rectangle whose corners have a right angle, which results in a problem that the corners chip or are abraded in a packaging step or the like of the manufacturing process. Further, in the conventional molded tablet manufacturing machine, the moist powder tends to stick to the rolling device or the ejector pins so that there occurs dispersion in weight of tablets to be products, or the surface of the tablet becomes rough. Thus, the molded tablets are disadvantageous in respect of efficiency of production, accuracy and quality. Similarly, such sticking of the moist powder results in another problem that split lines, product marks or the like can not be stamped on the tablets.
Meanwhile, almost all the tablets now available in the market belong to the compressed tablets. An apparatus for manufacturing the compressed tablets molds dry granules at a relatively high pressure of 100 to several thousands kg/cm
2
. This machine is generally called a tablet machine. The tablet machine comprises an upper rod, a lower rod and a mill. By applying force from the upper and lower rods to the granules supplied in the mill, the granules are pressurized and instantaneously formed into a tablet. A rotary-type tablet machine ordinarily includes 10 to 100 sets of an upper rod, a lower rod and a mill which are attached to a turn table. By using the rotary-type tablet machine, it is possible to manufacture tablets of the same number as that of the sets of the upper and lower rods and the mill during one rotation of the turn table. There is a tablet machine having a maximum tablet manufacturing capacity of 8,000 per one minute. The compressed tablets are appropriate for mass production, and superior to the molded tablets in respect of accuracy and quality. However, since the dry granules are compressed at the high pressure, the compressed tablets are inferior to the molded tablets as for the solubility and collapsibility.
As mentioned above, although the compressed tablets are superior to the molded tablets in view of efficiency of production, the molded tablets having the excellent solubility and collapsibility are suitable for persons of advanced age and infants to take, who are low in organic and physiological function. Accordingly, by developing a method of effectively mass-producing tablets of high mechanical strength, accuracy and quality which are easy for the persons of advanced age and infants to take, without deteriorating the aforesaid characteristics of the molded tablets, a remarkable merit can be realized in the field of medicines.
SUMMARY OF THE INVENTION
The present invention aims to solve the above-described problems of the prior art, and it is an object of the invention to provide a method and an apparatus for efficiently manufacturing tablets of moist powder which are high in accuracy and quality.
It is another object of the invention to provide a method and an apparatus for efficiently manufacturing tablets of high accuracy and quality which are easy for persons of advanced age and infants to take, by solving the problem of sticking of moist powder.
To achieve the above object, according to the invention, a first table including a plurality of filling holes and a second table including a plurality of mold cavities are prepared, and the second table partially contacts with the first table and relatively moves with respect to the first table. A predetermined amount of moist powder is supplied in the filling holes of the first table. The moist powder supplied in the filling holes is filled into the mold cavities of the second table under a pressurized condition by means of filling pins at a location where the filling holes of the first table are laid above the mold cavities of the second table. Then, the first and second tables are moved relatively with respect to each other so as to level the surface of the moist powder in the mold cavities by removing the excessive powder, prior to finishing tablets.
Accordingly, since the surface of the moist powder is leveled after it has been pressurized, it is easy to deal with the moist powder so that productivity is improved, a ratio of void defect of a tablet is lowered, and dispersion of weight and size of the tablet is minimized. It is thus possible to manufacture tablets of high precision and quality, which tablets are high in mechanical strength and superior in solubility and collapsibility.
Moreover, according to the invention, moist powder is filled in molding cavities, and at least one of the surfaces of the moist powder in each of the molding cavities is pressed by a molding die through a powder-intercepting film so as to form the moist powder into the shape of a tablet.
Therefore, the powder-intercepting film is interposed between the moist powder in the molding cavities and the molding dies, to thereby prevent the moist powder from sticking to the molding dies, which enables chamfering of the corners of the tablets and stamping of product marks and the like on the surfaces of the tablets. Thus, there can be achieved a method and an apparatus for efficiently manufacturing tablets of high accuracy and quality which are easy for persons of advanced age and infants to take.
REFERENCES:
patent: 2573141 (1951-10-01), Heinrich
patent: 2886849 (1959-05-01), Brierley
patent: 5603880 (1997-02-01), Kato et al.
patent: 5672364 (1997-09-01), Kato et al.
patent: 6074586 (2000-06-01), Brierley
Kato Heizaburo
Morita Yutaka
Nakajima Masaharu
Ohwaki Takayuki
Tsushima Yuki
Harness & Dickey & Pierce P.L.C.
Jones Kenneth M.
Sankyo Seisakusho Co & Eisai Co., Ltd.
Silbaugh Jan H.
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