Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus
Reexamination Certificate
2005-06-28
2005-06-28
Nguyen, Nam (Department: 1753)
Chemistry: electrical and wave energy
Apparatus
Electrophoretic or electro-osmotic apparatus
C204S660000, C204S663000, C204S666000, C239S690000, C366S349000
Reexamination Certificate
active
06911132
ABSTRACT:
An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An additional surface can be provided parallel with the first surface for the purpose of containing the droplets to be manipulated. Droplets are manipulated by performing electrowetting-based techniques in which electrodes contained on or embedded in the first surface are sequentially energized and de-energized in a controlled manner. The apparatus enables a number of droplet manipulation processes, including merging and mixing two droplets together, splitting a droplet into two or more droplets, sampling a continuous liquid flow by forming from the flow individually controllable droplets, and iterative binary or digital mixing of droplets to obtain a desired mixing ratio.
REFERENCES:
patent: 5468374 (1995-11-01), Knoll
patent: 5911533 (1999-06-01), Fassler et al.
patent: 5921678 (1999-07-01), Desai et al.
patent: 5980719 (1999-11-01), Cherukuri et al.
patent: 6057149 (2000-05-01), Burns et al.
patent: 6086243 (2000-07-01), Paul et al.
patent: 6109717 (2000-08-01), Kane et al.
patent: 6110426 (2000-08-01), Shalon et al.
patent: 6130098 (2000-10-01), Handique et al.
patent: 6136212 (2000-10-01), Mastrangelo et al.
patent: 6154226 (2000-11-01), York et al.
patent: 6170981 (2001-01-01), Regnier et al.
patent: 6211477 (2001-04-01), Cardott et al.
patent: 6213151 (2001-04-01), Jacobson et al.
patent: 6231177 (2001-05-01), Cherukuri et al.
patent: 6294063 (2001-09-01), Becker et al.
patent: 6318970 (2001-11-01), Backhouse
patent: 6352838 (2002-03-01), Krulevitch et al.
patent: 6379929 (2002-04-01), Burns et al.
patent: 6565727 (2003-05-01), Shenderov
patent: 2002/0043463 (2002-04-01), Shenderov
patent: 2003/0183525 (2003-10-01), Elrod et al.
patent: 2003/0205632 (2003-11-01), Kim et al.
patent: 2004/0007377 (2004-01-01), Fouilett et al.
Ding et al., “Reconfigurable Microfluidic System Architecture Based on Two-Dimensional Electrowetting Arrays,” Modeling and Simulation of Microsystems (Mar. 19-21, 2001), pp. 181-185.
Pollack et al., “Electrowetting-based actuation of liquid droplets for microfluidic applications,” Appl. Phys. Letters, vol. 77, No. 1 (Sep. 11, 2000), pp. 1725-1726.
U.S. Provisional App. No. 60/220,803.
PCT International Search Report for PCT/US03/12754 dated Sep. 1, 2004.
Pollack, “Electrowetting-Based Microactuation of Droplets for Digital Microfluidics,” Dissertation presented to Duke University Graduate School, Department of Electrical and Computer Engineering, 2001.
Pollack et al., “Electrowetting-Based Actuation of Droplets for Integrated Microfluidics,”Lab Chip, vol. 2, pp. 96-101, 2002.
Lee et al., “Microactuation by Continuous Electrowetting Phenomenon and Silicon Deep Rie Process”, Proc. MEMS (DSC—vol. 66) ASME Int. Mechanical Engineering Congress and Exposition, Anaheim, CA, Nov. 1998, pp. 475-480.
Lee et al., “Liquid Micromotor Driven by Continuous Electrowetting”, Proc. IEEE, Micro Electro Mechanical Systems Workshop, Heidelberg, Germany, Jan. 1998, pp. 538-543.
Fowler et al., “Enhancement of Mixing by Droplet-Based Microfluidics”, IEEE, 2002, pp. 97-100.
Pamula et al., “Microfluidic electrowetting-based droplet mixing”, IEEE, 2002, pp. 8-10.
Saeki et al., “Electrowetting on Dielectrics (EWOD): Reducing Voltage Requirements for Microfluidics”, Polym. Mater. Sci. Engr., vol. 85, pp. 12-13.
Vivek et al., “Novel Acoustic-Wave Micromixer,” IEEE International Micro Electro Mechanical Systems Conference, Miyazaki, Japan, Jan. 23-27, 2000, pp. 668-673.
Yang et al., “Ultrasonic Micromixer for Microfluidic Systems”, MEMS'2000, pp. 80-85.
Yang et al., “Micromixer Incorporated with Piezoelectrially Driven Valveless Micropump”, Micro Total Analysis Systems' 98, Kluwer Acad. Pub, Dordrecht, Boston and London, pp. 177-180, 1998.
Lee et al., “Chaotic Mixing in Electrokinetically and Pressure Driven Micro Flows”, Rhw 14thIEEE Workshop on MEMS, Jan. 2001.
Evans et al., “Planar Laminar Mixer”, Proceeding of the IEEE 10th Annual Workshop of MEMS (MEMS '97), Nagoya, Japan, pp. 96-101, Jan., 1997.
Choi et al., “An Active Micro Mixer Using Electrohdrodynamic (EHD) Convection”, Technical Digest of Solid-State Sensor and Actuator Workshop, Hilton Head Island, SC, pp. 52-55, 2000.
Miyake et al., “Micro Mixer with Fast Diffusion”, IEEE, pp. 248253, 1993.
Veenstra et al. “Characterization method for a new diffusion mixer applicable in micro flow injection analysis systems”, Journal of Micromechanics and Microengineering, 9, (2), pp. 199-202, 1999.
Branebjerg et al., “Fast mixing by lamination”, in Proc. of the 9th IEEE Micro Electro Mechanical Systems Workshop, eds. M. G. Allen and M. L. Reed (San Diego, Calif.) pp. 441-446, 1996.
Krog et al., “Experiments and Simulations on a Micro-Mixer Fabricated using a Planar Silicon/Glass Technology”, Microelectromechanical Systems (MEMS) DSC-vol. 59, ASME, pp. 177-182, 1996.
Schwesinger et al., “A Modular Microfluid System with an Integrated Micromixer”, J. Micromech.Microeng. vol. 6, IOP Publishing Ltd., pp 99-102, Mar. 1996.
Schwesinger et al., “A Static Micromixer Built Up in Silicon”, Proc. SPIE vol. 2642, pp 150-155, Sep., 1995.
Koch et al., “Two Simple Micromixers Based on Silicon”, J. Micromech. Microeng. vol. 8, pp. 123-126, Jun. 1998.
Koch et al., “Micromachined Chemical Reaction System”, Elsevier, Sensors and Actuators, vol. 74, pp. 207-210, 1999.
Koch et al., “Improved Characterization Technique for Micromixers”, J. Micromech.Microeng. vol. 9, pp. 156-158, 1998.
Kämper et al., “Microfluidic Components for Biological and Chemical Microreactors”, IEEE, pp. 338-343,.
Bertsch et al., “3D Micromixers—Downscaling Large Scale Industrial Static Mixers”, IEEE, pp. 507-510, 2001.
Voldman, “An Integrated Liquid Mixer/Valve”, Journal of Microelectromechanical Systems, vol. 9, No. 3, pp. 295-302, Sep., 2000.
Hosokawa et al., “Droplet-Based Nano/Picoliter Mixer using Hydrophobic Microcapillary Vent”, Twelfth IEEE International Conference on Micro Electro Mechanical Systems, IEEE, pp. 388-393, Jan. 1999.
Hosokawa et al., “Handling of Picoliter Liquid Samples in a Poly (dimethysiloxane)-Based Microfluidic Device”, Anal. Chem., vol. 71, pp. 4781-4785, 1999.
Masao Washizu, “Electrostatic Actuation of Liquid Droplets for Microreactor Applications”, IEEE Transactions on Industry Applications, vol. 34, No. 4, pp. 732-737, Jul./Aug. 1998.
Burns et al., “An Integrated Nanoliter DNA Analysis Device”, Science, vol. 282, pp. 484-487, 1998.
Pollack et al., “Electrowetting-based Actuation of Liquid Droplets for Microfluidic Applications”, Applied Physics Letters, vol. 77, No. 11, pp. 1725-1726, Sep. 11, 2000.
deRuijter et al., “Droplet Spreading: Partial Wetting Regime Revisited”, Langmuir, vol. 15, pp. 2209-2216, 1999.
Dussan V. et al. “On the Motion of a Fluid-Fluid Interface Along a Solid Surface”, J. Fluid Mech., vol. 65, pp. 71-95, 1974.
E.B. Dussan V., “Immiscible Liquid Displacement In A Capillary Tube: The Moving Contact Line”, AlChe Journal, vol. 23, No. 1, pp. 131-133, Jan., 1977.
E.B. Dussan V., “On the Spreading of Liquids on Solid Surfaces: Static and Dynamic Contact Lines”, Ann. Rev. Fluid Mech., vol. 11, pp. 371-400, 1979.
Huh et al., “Hydrodynamic Model of Steady Movement of a Solid/Liquid/Fluid Contact Line”, Journal of Colloid and Interface Science, vol. 35, No. 1, pp. 85-101, Jan. 1971.
Liu et al., “Passive Mixing in a Three Dimensional Serpentine Microchannel”, Journal of Microelectromechanical Systems,
Fair Richard B.
Paik Philip Y.
Pamula Vamsee K.
Pollack Michael G.
Ren Hong
Duke University
Jenkins & Wilson & Taylor, P.A.
Mutschler Brian L.
Nguyen Nam
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