Chemical apparatus and process disinfecting – deodorizing – preser – Physical type apparatus – Means separating or dissolving a material constituent
Reexamination Certificate
2000-04-05
2003-04-29
Thornton, Krisanne (Department: 1744)
Chemical apparatus and process disinfecting, deodorizing, preser
Physical type apparatus
Means separating or dissolving a material constituent
C422S285000, C424S078310, C424S195110, C426S437000, C435S283100
Reexamination Certificate
active
06555074
ABSTRACT:
FIELD OF THE INVENTION
The present invention is directed to a method and apparatus for making herbal extracts, and in particular, a method and apparatus that employs cold percolation to extract high levels of active principles from any herbal material for improved economic and medicinal effects.
BACKGROUND ART
In the prior art, herbal extracts and tinctures are commonly made using one or more solvents to extract one or more active principles contained in the herbaceous raw material being treated. Extraction techniques used to date include either percolation or maceration techniques.
U.S. Pat. No. 4,952,603 to Elferaly et al. teaches a method of isolation of artemisinin from Artemisia annua. In this method, dried unground leaves of Artemisia are extracted by continuous hot percolation over a period of 48 hours using n-hexane as a solvent. Hot percolation is akin to the percolation of coffee wherein the liquid is heated to boiling to achieve extraction of the material being treated.
Another known technique for the extraction of active principles from an herbaceous material is maceration. In this process, the herbaceous material is combined with one or more solvents and allowed to steep for a period of time, usually 14-38 days. The batch is usually mixed or stirred twice daily. During this steeping period, the active principles are extracted into the solvent and the active principle-containing solvent is drawn off after the period of steeping is complete.
The prior art also uses a percolation system whereby the solvent is merely allowed to percolate or pass through the herbaceous raw material.
FIG. 1
shows an exemplary percolation apparatus designated by the reference numeral
10
. In this process, a conical or cylindrical vessel
1
with a stopcock
3
at the base thereof is used. The vessel is supported by members
4
. The vessels can be made of glass, copper or stainless steel. Typically, the depth of the material to be processed is about 5 times the diameter of the cylindrical percolator. For example, a percolator having a 4.5-inch diameter would require a column height of 22.5 inches for the material. Prior to the actual percolation, the material is comminuted to a particular size and soaked in the solvent or menstruum to be used for about 2 hours. This allows the material to swell prior to being charged to the percolator vessel. The comminution should be sufficient to allow the material to be in contact with-the solvent but should not be too fine to cause clogging during the percolation process. The degree of comminution depends on the herbaceous material. For most herbs, a tealeaf cut is preferred, i.e., having particles the size of tealeaves.
Prior to charging the vessel, a sieve plate
5
and a wad of cotton or filter paper
7
are placed in the vessel
1
, preferably in the neck thereof, to prevent the stopcock
3
from clogging. The sieve plate
5
also supports the charge of material
9
.
The pre-swollen drug as the charge, also known as the marc, is then placed in the vessel
1
on top of the sieve plate
5
, and distributed so that channels are not formed that would allow uneven flow of the solvent through the marc
9
.
The marc
9
is then covered with filter paper
11
, weighted down with glass beads
13
, and covered with a lid
15
. The solvent is then poured onto the filter paper/glass bead layer and allowed to saturate the marc
9
. The stopcock is open during this step to force air out of bottom of the vessel and through the stopcock.
As soon as the liquid
21
begins to drip out into the beaker
23
, the stopcock
3
is closed and the marc is allowed to macerate for a period of about 24 hours. The extract is then allowed to drip out at a percolation rate of about 4-6 drops per minute for each 100 grams of crude material. For 1000 grams of material, the rate would be 40-60 drops per minute.
The first run of the solvent has the highest percentage of active principles and is commonly referred to as first runnings or extraction head. The first runnings generally extract about 45% of the active principles. A second run or pass would produce an extract with about 23% with a third run or pass having about 12%. A fourth pass would have about 3% and a fifth pass has about 1%. In this one through process, there is an ever-diminishing return with about 84% of the active principles recovered.
The prior art techniques mentioned above have drawbacks that hinder the efficient and effective extraction of active principles from herbaceous raw materials. In the percolation technique, production is very slow and only about 45% of the active principles are recovered at best in the first runnings. In addition, solvent evaporation is high, thus contributing to increased costs.
Maceration techniques take too long, and only recover 35-38% of the active principles from the herb. The prior art percolation technique fails in its ability to extract many of the active principles in the herb and is also slow in its once through processing.
As such, a need has developed to provide improved ways to extract active principles from herbs/plants that overcome the disadvantages known in the prior art. The present invention solves the prior art problems by providing a method and apparatus that extracts active principles from herbaceous raw materials more economically and in concentrations providing enhanced medicinal effects to users.
SUMMARY OF THE INVENTION
Accordingly, it is a first object of the present invention to provide an improved apparatus for making herbal extracts.
Another object of the present invention is a method of manufacturing herbal extracts.
A still further object of the present invention is a method and apparatus for making herbal extracts that are economically attractive.
Yet another object of the invention is a method and apparatus that produces herbal extracts with increased levels of active principles over prior art techniques.
One other object of the present invention is a method of using high concentration extracts in lower unit doses for patient use.
A still further object of the invention is a method and apparatus that extracts a large majority of the active principles of an herbaceous material, whether identified or not for medicinal purposes.
Other objects and advantages will become apparent as a description thereof proceeds.
In satisfaction of the foregoing objects and advantages, the present invention is an advancement of the prior art techniques of hot percolation, percolation, and maceration for producing herbal extracts. The inventive apparatus is an improvement in percolation apparatus that use a percolation vessel with an inlet end and a discharge end, a valve positioned upstream from the discharge end, and a filter in the vessel to support a bed of herbal material. The inventive apparatus uses a pump, an inlet of the pump connected to the discharge end of the vessel and a pump outlet connected to the inlet end of the vessel. A heater is positioned adjacent to the vessel and a temperature sensing and control device is provided for controlling output of the heater and for maintaining the bed of herbal material and liquid passing therethrough at an elevated temperature between room temperature and but no higher than to 60° C.
Preferably, the heater is heating tape or a heating belt that is wrapped around the exterior of the vessel. The temperature control device can include a thermocouple or probe, the probe preferably inserted into the vessel adjacent a wall thereof.
The pump is preferably a peristaltic type. A number of vessels can be used in the same or similar sizes to enhance production. If desired, a single pump can be employed to recirculate the extract for each of the plurality of vessels.
The components of the system are preferably inert materials such as glass, food grade polymers (norprene or tygon tubing) and the like to ensure a high quality output from the vessels once the process is terminated. Additional filters can be provided to clarify the extract once produced.
The inventive method is an improvement over prior art percolation methods that
Clark & Brody
Thornton Krisanne
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