Apparatus for interfacing liquid chromatography-mass spectrometr

Details Apparatus for interfacing liquid chromatography-mass spectrometr Apparatus for interfacing liquid chromatography-mass spectrometr

1991-10-08

1993-06-29

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

210656, 55 15, 55 17, 552571, 55261, 55267, 55277, 55386, 250288, B01D 1508

Patent

active

052231313

ABSTRACT:
Close coupled momentum separator with integral removable source volume for particle beam liquid chromatography/mass spectrometry is provided. The inventive PB LC/MS system comprises a momentum separator wherein the skimmers are designed to accommodate the particle beam conical dispersion so as to minimize the number of particles lost in the separator. In addition, the exit of the momentum separator is closely coupled to the entrance of the MS source volume. The PB LC/MS system demonstrates improved linearity in signal and enhanced sensitivity.

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patent: 4863491 (1989-09-01), Brandt
patent: 4980057 (1990-12-01), Dorn
McLaughlin, "Particle Bean LC/MS for Drug Testing: Influence of Carrier Effect on Quantitation", 6th (Montreaux) Symposium on Liquid Chromatography/Mass Spectrometry (1990), p. 227.
Behymer, "Liquid Chromatography/Particle Beam/Mass Spectrometry of Polar Components of Environmental Interest", Anal. Chem., 62, 1990, pp. 1686-1690.
Bellar, "Investigation of Enhanced Ion Abundances from a Carrier Process in High Performance Liquid Chromatography Particle Beam Mass Spectrometry", J. Am. Soc. Mass Spectrom., 1, 1990, pp. 92-98.
Willoughby, "Monodispeese Aerosol Generation Interface, for Combining Liquid Chromatography with Mass Spectrometry", Anal. Chem., 56, 1984, pp. 2626-2631.

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