Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Chemiluminescent
Patent
1995-06-05
1998-07-14
Alexander, Lyle A.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Chemiluminescent
422 8205, 436172, G01N 2166
Patent
active
057799768
ABSTRACT:
An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
REFERENCES:
patent: 3319132 (1967-05-01), Chandross
patent: 3970518 (1976-07-01), Giaever
patent: 4070246 (1978-01-01), Kennedy et al.
patent: 4115535 (1978-09-01), Giaever
patent: 4169804 (1979-10-01), Yapel, Jr.
patent: 4280815 (1981-07-01), Oberhardt et al.
patent: 4305925 (1981-12-01), Kapmeyer et al.
patent: 4419453 (1983-12-01), Dorman et al.
patent: 4431919 (1984-02-01), Kostlin et al.
patent: 4447546 (1984-05-01), Hirschfeld
patent: 4480042 (1984-10-01), Craig et al.
patent: 4515890 (1985-05-01), Manderino et al.
patent: 4539507 (1985-09-01), VanSlyke et al.
patent: 4554088 (1985-11-01), Whitehead et al.
patent: 4628037 (1986-12-01), Chagnon et al.
patent: 4652333 (1987-03-01), Carney
patent: 4652533 (1987-03-01), Jolley
patent: 4661444 (1987-04-01), Li
patent: 4677067 (1987-06-01), Schwartz et al.
patent: 4695392 (1987-09-01), Whitehead et al.
patent: 4695393 (1987-09-01), Whitehead et al.
patent: 4698302 (1987-10-01), Whitehead et al.
patent: 4731337 (1988-03-01), Luotola et al.
patent: 4745077 (1988-05-01), Holian et al.
patent: 4777145 (1988-10-01), Luotola et al.
patent: 4849340 (1989-07-01), Oberhardt
patent: 4865997 (1989-09-01), Stoker
patent: 4916081 (1990-04-01), Kamada et al.
patent: 4945045 (1990-07-01), Forrest et al.
patent: 4978610 (1990-12-01), Forrest et al.
patent: 5061445 (1991-10-01), Zoski et al.
patent: 5068088 (1991-11-01), Leventis et al.
patent: 5093268 (1992-03-01), Hall et al.
patent: 5115534 (1992-05-01), Fournier
patent: 5240863 (1993-08-01), Shibue et al.
patent: 5310687 (1994-05-01), Bard et al.
patent: 5324457 (1994-06-01), Zhang et al.
patent: 5521319 (1996-05-01), Huber et al.
patent: 5536472 (1996-07-01), Terashima et al.
Abruna, J. Electrochem. Soc. 1985, 132, 842.
Beaucage SL, Caruthers MH. Deoxynucleoside phosphoramidites, a new class of key intermediates for deoxypolynucleotide synthesis. Tetrahedron Lett 1982; 22:1859-62.
Cardullo RA, Agrawal S, Flores C, Zamecnik DC, Wolf DE. Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer. Proc. Natl. Acad. Sci. 1988; 85:8790-4.
Casadei J, Powell MJ, Kenten JH. Expression and secretion of aequorin as a chimeric antibody using a mammalian expression vector. Proc. Natl. Acad. Sci. 1990; 87:2047-51.
Coutlee F, Bobo L, Mayur K, Yolken RH, Viscidi RP. Immunodetection of DNA with biotinylated RNA probes: A study of reactivity of a monoclonal antibody to DNA-RNA hybrids. Anal. Biochem. 1989; 181:96-105.
Devices, Japanese Journal of Applied Physics, vol. 18, No. 7, 1979, 1295-1301.
Dulbecco, R., and Freeman, G., (1959) Virology B, 398.
Dynal, Dynabeads, M-450; Dynal A.S. Oslo, Norway, Product Literature. No date supplied.
Ege, et al., J. Anal. Chem. 1984, 56, 2413.
Faulkner, L.R. et al., J.Am. Chem. Soc. 94 , 691 (1972).
Hamblen, et al., "Characteristics of an Electrically Controlled Fluorescent Dye Panel", IEEE Conference Record of 1972, Conference on Display Devices, Oct. 11-12, (1972).
Hemingway, et al., "Electrogenerated Chemiluminescence. XXI. Energy Transfer from an Exciplex to a Rare Earth Chelate", J. Am. Chem. Soc. 1975, 97: 1, 200-01.
Heney, G. and Orr, G.A. (1981) Anal. Biochem. 114, 92-96.
Iscove, N.N. and Melchers, F., J. Experimental Medicine 147, 923; No Date Supplied.
Itaya, et al., "Electrogenerated Chemiluminescence with Solvated Electrons in Hexamethylphosphoramide. 2", J. Am. Chem. Soc. 1978, 100: 19, 5996-6002.
Keszthelyi, et al., "Electrogenerated Chemiluminescence. XV. On the Formation of Excimers and Exciplexes in ECL", Chemical Physics Letters 1974, vol. 24, No. 2, 300-04.
Keszthelyi, et al., "Electrogenerated Chemiluminescence. XIV. Effect of Supporting Electrolyte Concentration and Magnetic Field Effects in the 9, 10-Dimethylanthracene-tri-p-tolylamine in Tetrahydrofuran", Chemical Physics Letters 1973, vol. 23, No. 2, 219, 220-22.
Kohen et al., "Chemiluminescence & Bioluminescence Immunoassay", Alternative Immunoassays, W.P. Collins, (1985) John Wiley & Sons, Ltd., Chap. 8, pp. 103-109.
Ludvik, et al., J. Electroanal. Chem. 1986, 215, 179.
Lyons J, Janssen JWG, Bartram C, Layton M, Mufti GJ. Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes. Blood 1988; 71;1707-12.
Lytle, et al., Photochem. Photobiol. 1971, 13, 123.
Maloy, et al., "Electrogenerated Chemiluminescence. II. The Rotating-Ring Disk Electrode and the Pyrene-N,N,N',N'-Tetramethyl-p-phenylenediamine System", J. Phys. Am. Chem. 1968, vol. 72, No. 12, 4348-50.
Marmur, J. (1961) J. Mol. Biol. 3, 208.
Mullis KB, Faloona FA. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol 1987; 155:335-50.
Ngo TT. Procedure for activating polymers with primary and/or secondary hydroxyl groups. Makromol Chem. Macromol Symp. 1988; 17:224-39.
Noffsigner, et al., Anal. Chem. 1987, 59, 865.
Pragst, et al., "Electrogenerated Chemiluminescence in Mechanistic Investigations of Electroorganic Reactions, Part I. Cathodic Cleavage of Bis-(2, 4, 5-Triphenylimidazolyl)-1,2 (Dilophyl), " J. Electroanal. Chem. 1980, 112, 339.
Pragst, et al., a J. Electroanal. Chem. 1986, 197, 245.
Reddy Ep, Reynolds Rk, Santo E, Baracid M. A point mutation is responsible for the acquisition of the transforming properties by the T24 humanbladder carcinoma oncogene. Nature 1982; 300:149-52.
Rozhitskii, et al., "Steady-State Electrochemiluminescence in Solutions with Organometallic Electrolytes", J. Appl. Spectrosc. 1978, vol. 28, No. 2, 197-202.
Rubenstein, et al., "Electrogenerated Chemiluminescent Determination of Oxylate", Anal. Chem. 1983, 54, 9, 1580-82.
Rubinstein, et al., J. Am. Chem. Soc. 1981, 103, 512.
Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988; 239;487-91.
Sato, et al., "Quenching Of Fluorescence in Europium B-Diketone Chelate Solutions and Its Application to Display"; No Date Suppplied.
Shibata DK, Arnheim N, Martin JW. Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J. Exp. Med. 1988; 167:225-30.
Smith, J.D., Freeman, G., Vogt, M., and Dulbecco, R., (1960), Virology 12, 155.
Tachikawa, et al., "Electrogenerated Chemiluminescence. Effect on a Magnetic Field on the Delayed Fluorescence and ECL of Several Systems Involving Excimers or Exciplexes", Chemical Physics Letters 1974, vol. 26, No. 4, 568-73.
Tachikawa, et al., "Electrogenerated Chemiluminescence XII. Magnetic Field Effects on ECL in the Tetracene-TMPD System; Evidence for Triplet-Triplet Annihilation of Tetracene", Chemical Physics Letters 1973, vol. 19, No. 2, 287-89.
Tokel-Takvoryan, et al., "Electrogenerated Chemiluminescence. XIII. Electrochemical and Electrogenerated Chemiluminescence Studies of Ruthenium Chelates", J. Am. Chem. Soc. 1973, 95: 20, 6582-89.
Updyke TV, Nicolson GL. Immunoaffinity isolation of membrane antigens with biotinylated monoclonal antibodies and streptavidin-agarose. Methods Enzymol 1986; 121:717-25.
Weetall, H.H. and Hotaling, T., Biosensors 3 (1987/88), 57-63.
Wheeler, et al., "A Silicon Phthalocyanine and a Silicon Naphthalocyanine: Synthesis, Electrochemistry, and Electrogenerated Chemiluminescence", J. Am. Chem. Soc. 1984, 106, 7404-10.
Wilson, et al., "Electrogenerated Chemiluminescence of trans-Stilbene Derivatives", J. Electrochem. Soc.: Electrochemical Science and Technology (1981), vol. 128, No. 10, 2085-89.
Yanofsky, C. et al. (1981) Nucle
Blackburn Gary F.
Goodman Jack E.
Kenten John Henry
Leland Jonathan K.
Lowke George E.
Alexander Lyle A.
IGEN International Inc.
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