Apparatus for high pressure peptide synthesis

Details Apparatus for high pressure peptide synthesis Apparatus for high pressure peptide synthesis

1981-03-10

1982-12-07

Marcus, Michael S.

Chemical apparatus and process disinfecting, deodorizing, preser

Chemical reactor

Organic polymerization

23230A, 2601125R, 422111, 422113, 422116, 422135, 422211, 422234, B01J 802, C07C10352, G05D 1600

Patent

active

043626998

ABSTRACT:
An apparatus for synthesizing a polypeptide chain on an insoluble solid support in a continuous flow reactor by performing a series of stepwise coupling reactions under high pressure is disclosed. A deprotecting agent reservoir, a solvent reservoir, a neutralizing solution reservoir, and a plurality of amino acid reservoirs are provided. Each reservoir can be selectively coupled to the reactor and a source of high pressure inert gas or an appropriate pump can be used to force the fluids as needed to the reactor. The reactor also includes a recycle loop whereby the amino acid from a particular reservoir can be recycled through the reactor under high pressure.

REFERENCES:
patent: 2761882 (1956-09-01), Hulse et al.
patent: 3531258 (1970-09-01), Merrifield et al.
patent: 3557077 (1971-01-01), Brufeldt et al.
patent: 3647390 (1972-03-01), Kubodera et al.
patent: 3951741 (1976-04-01), Pfaender et al.

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