Chemistry: molecular biology and microbiology – Apparatus
Patent
1997-07-25
1999-06-22
Lankford, Jr., Leon B.
Chemistry: molecular biology and microbiology
Apparatus
435325, 623 15, C12N 500, C12N 502, A61F 210
Patent
active
059142642
ABSTRACT:
A method of growing complete vertebrate skin in vitro, which comprises obtaining a segment of vertebrate skin, positioning the skin segment in an artificial cell-growth medium containing sufficient nutrients to maintain growth of cells of the skin, and subjecting the skin segment to stretching forces while the skin segment is in the medium. Skin produced by the method and an apparatus for carrying out the method are also part of the present invention.
REFERENCES:
Denefle et al. Biol Cell. 29(2-3). pp. 113-122, 1977.
Ono et al. Burns 19(4). pp. 283-288, 1993.
Argenta, L.C. et al., (1983) "The Use of Tissue Expansion in Head and Neck Reconstruction," Ann. Plast. Surg. 11:31-37.
Argenta, L.C. (1984) "Controlled Tissue Expansion in Reconstructive Surgery," Brit. J. Plas. Surg. 37:520-529.
Arons, J.A. et al., (1992) "The Surgical Applications and Implications of Cultured Human Epidermis: A Comprehensive Review," Surgery 111(1) :4-11.
Carney, S.A. (1986) "Generation of Autograft; The State of the Art," Burns 12:231-235.
Dennis, L.W. (1992) "Tissue Cultured Skin Grafts," Journal of Burn Care & Rehabilitation 13(1) :93-94.
Eldad, A. et al., (1987) "Cultured Empithelium as a Skin Substitute," Burns 13(3) :173-180.
Gallico III, G.G. (1990) "Biologic Skin Substitutes," Clinics In Plastic Surgery 17(3) :519-526.
Greenwald, D.P. et al., (1992) "Full-Thickness Skin Wound Explants in Tissue Culture: A Mechanical Evaluation of Healing," Plastic and Reconstructive Surgery 90(2) :289-294.
Hiernickel, H. (1985) "An Improved Method For In Vitro Perfusion of Human Skin," British Journal of Dermatology 112:299-305.
Kirsner, R.S. et al., (1993) "The Biology of Skin Grafts," Arch Dermatol 129:481-483.
Nanchahal, J. and C.M. Ward, (1992) "New Grafts For Old? A Review of Alternatives to Autologous Skin," British Journal of Plastic Surgery 45:354-363.
Tanner, James C. et al. (1964) "Plastic and Reconstructive Surgery," 34:287-292.
Tanner, James C. et al. (1966) "American Journal of Surgery," 111:543-547.
Tanner, James C. et al. (1969) "Plastic and Reconstructive Surgery," 44:504-506.
Teepe, R.G.C. et al., (1993) "Randomized Trial Comparing Cryopreserved Cultured Epidermal Allografts With Tulle-Gras in the Treatment of Split-Thickness Skin Graft Donor Sites," The Journal of Trauma 35(6) :850-854.
Wong, L. and A.M. Munsten, (1993) "New Techniques in Burn Wound Management," Surgical Clinics of North America 73(2) :363-371.
Lankford , Jr. Leon B.
Reconstructive Technologies
LandOfFree
Apparatus for growing vertebrate skin in vitro does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for growing vertebrate skin in vitro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for growing vertebrate skin in vitro will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1707882