Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus
Patent
1990-01-30
1992-10-06
Warden, Robert J.
Chemistry: molecular biology and microbiology
Apparatus
Differentiated tissue perfusion or preservation apparatus
435289, 435316, C12M 300
Patent
active
051531364
ABSTRACT:
An apparatus for growing tissue specimens in vitro includes an expandable membrane for receiving a tissue specimen thereon, a mechanism for expanding the membrane and the tissue specimen, and a controller for controlling the expanding mechanism. The controller is operative for applying an activity pattern to the membrane and a tissue specimen thereon which includes simultaneous continuous stretch activity and repetitive stretch and release activity. The continuous stretch activity and the repetitive stretch and release activity simulate the types of activity to which cells are exposed in vivo due to growth and movement, respectively, and they cause the cells of tissue speciments grown in the apparatus to develop as three-dimensional structures similar to those grown in vivo.
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Beisner William H.
Warden Robert J.
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