Apparatus for growing cells under variable hydrostatic...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S283100, C435S289100, C435S304100, C435S305100

Reexamination Certificate

active

07435587

ABSTRACT:
This invention provides an apparatus for growing cells under static or dynamic physiological pressure which contains a cell culture cassette having a cassette frame; two side walls secured to each side of the cassette frame to form a cell growing chamber, and at least one side wall comprises a cell growth surface. The apparatus also contains a means for adjusting fluid pressure or flow, for providing culture media or cell culture, or for sampling cell culture or culture media within the cell growing chamber. The apparatus further contains an adapter which contains two side assemblies where each side assembly includes a frame with a rigid support that fits over the cell culture cassette. The side assemblies joined by a hinge at one end and positioned over the two side walls of the cell culture cassette. The apparatus further contains a means to secure the two side assemblies over the two side walls of the cell culture cassette.

REFERENCES:
patent: 4833089 (1989-05-01), Kojima et al.
patent: 4851354 (1989-07-01), Winston et al.
patent: 0 707 186 (1996-04-01), None
Ute Hansen, Michael Schumke, Christian Domm, Niki Ioannidis, Joachim Hassenpflug, Thorsten Gehrke, Bodo Kurz. “Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering,” Journal of Biomechanics 34, 941-949 (2001).
Cornelia Hasel, Susanne Durr, Silke Bruderlein, Ingo Melzner, Peter Moller. “A cell-culture system for long-term maintenance of elevated hydrostatic pressure with the option of additional tension,” Journal of Biomechanics 35, 579-584 (2002).
Jenneke Klein-Nulend, Jan Roelofsen, Cornelis M. Semeins, Antonius L.J.J. Bronckers, and Elisabeth H. Burger. “Mechanical Stimulation of Osteopontin mRNA Expression and Synthesis in Bone Cell Cultures,” Journal of Cellular Physiology 170, 174-181 (1997).
Thomas D. Brown. “Techniques for mechanical stimulation of cells in vitro: a review,” Journal of Biomechanics 33, 3-14 (2000).
Salwen SA, Szarowski DH, Turner JN, Bizios R. “Three-dimensional changes of the cytoskeleton of vascular endothelial cells exposed to sustained hydrostatic pressure,” Medical and Biological Engineering and Computing, 36(4), 520-527 (1998).
Nagatomi J, Arulanandam BP, Metzger DW, Meuniera, Bizios R. “Frequency- and duration-dependent effects of cyclic pressure on select bone cell functions,” Tissue Engineering, 7(6), 717-728(2.
Mitchell SB, Sanders JE, Garbini JL, Schuessler PK. “A device to apply user-specific strains to biomaterials in culture,” IEEE Trans Biomed Eng 48(2), 268-273, (2001).
Ozawa H, Imamura K, Abe E, Takahashi N, Hiraide T, Shibasaki Y, Fukuhara T, Suda T. “Effect of a continuously applied compressive pressure on mouse osteoblast-like cells (MC3T3-E1) in vitro,” Journal of Cellular Physiology, 142(1), 177-185 (1990).
Saito S, Ngan P, Rosol T, Saito M, Shimizu H, Shinjo N, Shanfeld J, Davidovitch Z. “Involvement of PGE synthesis in the effect of intermittent pressure and Interleukin-1—on bone resorption,” J Dent Res Jan, 70(1), 27-33 (1990).
Takano-Yamamoto T, Soma S, Nakagawa K, Kobayashi Y, Kawakami M, Sakuda M. “Comparison of the effects of hydrostatic compressive force on glycosaminoglycan synthesis and proliferation in rabbit chondrocytes from mandibular condylar cartilage, nasal septum, and spheno-occipital synchondrosis in vitro,” Am J Orthod Dentofacial Orthop, 99(5), 448-55 (1991).
Koyama S, Miwa T, Sato T, Aizawa M. “Optical chamber system designed for microscopic observation of living cells under extremely high hydrostatic pressure,” Extremophiles Dec., 5(6), 409-15, (2001).
Kaarniranta K, Elo MA, Sironen RK, Karjalainen HM, Helminen HJ, Lammi MJ. “Stress responses of mammalian cells to high hydrostatic pressure,” Biorheology 40, 87-92 (2003).
Tezel J G, Wax MB. “Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells,” The Journal of Neuroscience. 20(23), 8693-700, Dec. 1, 2000.
Nerucci F, Fioravanti A, Cicero MR, Marcolongo K, SpiHaset C, Durr S, Bruderlein S, Melzner I, Moller P. “Preparation of a pressurization system to study the effect off a hydrostatic pressure on chondrocyte cultures,” In Vitro Cellular & Developmental Biology. Animal 34:9-10, Jan. 1998.
Wax MB, Tezet G, Kobayashi S. Hernandez MR. “Responses of different cell lines from ocular tissues to elevated hydrostatic pressure,” Br J Ophthalmol 84, 423-428 (2000).
Saris DB, Sanyal A, An KN, Fitzsimmons JS, O'Driscoll SW. “Periosteum responds to dynamic fluid pressure by proliferating in vitro,” Journal of Orthopaedic Research 17(5), 668-677 (1999).
Suh JK, Baek GH, Aroen A, Malin CM, Niyibizi C, Evans CH, Westerhausen-Larson A. “Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism,” Osteoarthritis Cartilag, 7(I):71-80 (1999).
Carver SE, Heath CA. “Semi-continuous perfusion system for delivering intermittent physiological pressure to regenerating cartilage,” Tissue Engineering 5(I), 1-11 (1999).
Hartig M, Ulrich J, Haas-Peter Wiesmann. “Capacitively coupled electric fields accelerate proliferation of osteoblast-like primary cells and increase bone extracellular matrix formation in vitro,” Eur. Biophys J 29, 499-506 (2000).
Brighton CT, Wang W, Seldes R, Zhang G. and Pollack S. “Signal Transduction in Electrically Stimulated Bone Cells,” JBJS 83 A (10): 1514-23, (2001).
Hiroyuki Ozawa, Etsuko Abe, Yoshinobu Shibasaki, Tatsuo Fukuhara, and Tatsuo Suda. “Electric Fields Stimulate DNA Synthesis,of Mouse Osteoblast-Like Cells (MC3T3-E1) by a Mechanism Involving Calcium Ions,” Journal of Cellular Physiology 138:477-483 (1989).
Peter F. Armstrong, Carl T. Brighton, and Andrew M. Star. “Capacitively Coupled Electrical Stimulation of Bovine Growth Plate Chondrocytes Grown in Pellet Form,” Journal Orthopaedic Research 6:265-271, (1988).
Gunter Fuhr, Henning Glasser, Torsten Muller, Thomas Schnelle. “Cell manipulation and cultivation under a.c. electric field influence in highly conductive culture media,” Biochimica et Biophysica Acta 1201, 353-360 (1994).
Carl T. Brighton, M.D., Ph.D., Enyi Okereke, M.D., Solomon R. Pollack, Ph.D., Charles C. Clark, Ph.D., “In Vitro Bone-Cell Response to a Capacitively Coupled Electrical Field,” Clinical Orthopaedics and Related Research. No. 285, 255-62 (1992).
Korenstein R. Somjen D. Fischler H. Binderman I. “Capacitative pulsed electric stimulation of bone cells induction of cyclic amp changes and DNA synthesis,” Biochimica et Biophysica Acta. 803(4):302-7 (1984).
Karen M. Haberstroh, Martin Kaefer, Natacha DePaola, Sarah A. Frommer, Rena Bizios. A Novel In-Vitro System for the Simultaneous Exposure of Bladder Smooth Muscle Cells to Mechanical Strain and Sustained Hydrostatic Pressure, Journal of Biomechanical Engineering 124, 208-213 (2002).
U.S. Appl. No. 10/378,585, filed Mar. 3, 2003, DiResta et al.
U.S. Office Action for DiResta, et al., U.S. Appl. No. 10/378,585, filed Mar. 3, 2003, dated Jan. 13, 2006.
U.S. Office Action for DiResta, et al., U.S. Appl. No. 10/378,585, filed Mar. 3, 2003, dated Jul. 5, 2006.
U.S. Office Action for DiResta, et al., U.S. Appl. No. 10/378,585, filed Mar. 3, 2003, dated Mar. 26, 2007.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Apparatus for growing cells under variable hydrostatic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Apparatus for growing cells under variable hydrostatic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for growing cells under variable hydrostatic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4008498

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.