Apparatus for gene therapy

Details Apparatus for gene therapy Apparatus for gene therapy

1995-06-02

1997-12-30

Buiz, Michael Powell

Surgery

Controlled release therapeutic device or system

Osmotic or diffusion pumped device or system

604173, 604306, 4351721, 43524021, A61K 922, C12N 1500

Patent

active

057023840

ABSTRACT:
There is provided an apparatus for gene therapy to transfer or introduce, in vivo, a gene for treatment into a cell located at a target portion of a patient, so that the gene can be transferred with a high probability within a short period of time. The apparatus is applicable to all cell species. In addition to simple supply of a gene to the cell of the patient, the gene is forcibly transferred to the cell without depending on natural cellular physiology. For example, catheters are mounted on a probe inserted into a body cavity, and the gene is supplied from a reservoir which stores the gene to the surface of a human living cell of the target portion in the body cavity through needle cannulas attached to the distal ends of the catheters. A pulse voltage is applied to the needle cannulas to form a pore in the surface of the human living cell upon application of the pulse voltage. The gene is transferred into the human living cell through the pore.

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