Apparatus for encapsulating biological active substances into er

Details Apparatus for encapsulating biological active substances into er Apparatus for encapsulating biological active substances into er

1986-11-20

1988-06-21

Scott, Samuel

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

435 2, 435316, 21032172, C12M 100

Patent

active

047525860

ABSTRACT:
This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at least one dialysis element is continuously supplied with an aqueous suspension of erythrocytes, the secondary compartment of the dialysis element contains an aqueous solution which is hypotonic with respect to the erythrocyte suspension in order to lyse the erythrocytes, the erythrocyte lysate is in contact with said substance having a biological activity and, in order to reseal the membrane of the erythrocytes, the osmotic and/or oncotic pressure of the erythrocyte lysate is increased after it has been brought into contact with said substance having a biological activity.

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