Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing gas sample
Patent
1996-12-23
1999-09-28
Pyon, Harold Y.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing gas sample
422100, 422102, 422104, 422 63, B01L 1100
Patent
active
059583410
ABSTRACT:
Slideholders which are useful for manually processing tissue samples on microscope slides are described. These slideholders hold multiple slides and are designed in conjunction with specialized trays for rapidly processing the mounted tissue samples such as for immunocytochemical staining. The slideholder plus tray assemblies incorporate several useful advantages including a requirement for minimal reaction fluid volumes, ease of handling several slides concurrently, prevention of evaporation of reaction fluids, protection of the tissue from extraneous environmental contamination, and the ability to perform in situ PCR. Various aspects of the design aid in removing trapped air from the reaction fluids and in adding fluids to the tissue sample. One embodiment comprises a coverslip with a soft top which aids in prevention of tissue degradation by preventing pressure buildup during PCR. The system results in very low background signals and allows for manually processing manifold times the number of slides as is typically possible with other current manual methods.
REFERENCES:
patent: 4336765 (1982-06-01), Coughlin
patent: 4347750 (1982-09-01), Tersteeg et al.
patent: 4595561 (1986-06-01), Thornton et al.
patent: 4731335 (1988-03-01), Brigati
patent: 4777020 (1988-10-01), Brigati
patent: 4798706 (1989-01-01), Brigati
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4801431 (1989-01-01), Cuomo et al.
patent: 4975250 (1990-12-01), Mordecki
patent: 4985206 (1991-01-01), Bowman et al.
patent: 5002736 (1991-03-01), Babbitt et al.
patent: 5021218 (1991-06-01), Davis et al.
patent: 5023187 (1991-06-01), Koebler et al.
patent: 5192503 (1993-03-01), McGrath et al.
patent: 5269918 (1993-12-01), Lapidus et al.
patent: 5318749 (1994-06-01), Eberle
patent: 5364790 (1994-11-01), Atwood et al.
patent: 5439649 (1995-08-01), Tseung et al.
Description of Dakostainer Universal Staining System (one page).
Description of SlideMaster from Lab Vision Corporation (two pages).
Description of Stainplate.TM. Staining Accelerator from Signet Laboratories, Inc. (one page).
Description of the Ventana ES IHC Staining System (3 pages).
Description of the Shandon Lipshaw Cadenza.RTM. Automated Immunostainer (5 pages).
D. Brigati et al. (1988). "Immunocytochemistry is Automated: Development of A Robotic Workstation Based Upon the Capillary Action Principle," J. Histotechnology 11:165-183.
C.M. McGrath et al. (1995). "Influence of Surface:Volume Ratio of Reaction Chambers on Stoichiometry of Antibody-Based Reactions In Situ," Cell Vision 2:165-169.
G.J. Nuovo (1994). "In Situ Detection of PCR-amplified DNA and cDNA: A Review" J. Histotechnology 17:235, 240-242.
American Registry of Pathology
Pyon Harold Y.
LandOfFree
Apparatus for efficient processing of tissue samples on slides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for efficient processing of tissue samples on slides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for efficient processing of tissue samples on slides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-699785